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| Content Provider | Springer Nature Link |
|---|---|
| Author | Mao, Xing gang Zhang, Xiang Zhen, Hai ning |
| Copyright Year | 2008 |
| Abstract | The identification of brain tumor stem cells (BTSCs) leads to promising progress on brain tumor treatment. For some brain tumors, BTSCs are the driving force of tumor growth and the culprits that make tumor revive and resistant to radiotherapy and chemotherapy. Therefore, it is specifically significant to eliminate BTSCs for treatment of brain tumors. There are considerable similarities between BTSCs and normal neural stem cells (NSCs), and diverse aspects of BTSCs have been studied to find potential targets that can be manipulated to specifically eradicate BTSCs without damaging normal NSCs, including their surface makers, surrounding niche, and aberrant signaling pathways. Many strategies have been designed to kill BTSCs, and some of them have reached, or are approaching, effective therapeutic results. Here, we will focus on advantages in the issue of BTSCs and emphasize on potential therapeutic strategies targeting BTSCs. |
| Starting Page | 141 |
| Ending Page | 155 |
| Page Count | 15 |
| File Format | |
| ISSN | 02724340 |
| Journal | Cellular and Molecular Neurobiology |
| Volume Number | 29 |
| Issue Number | 2 |
| e-ISSN | 15736830 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2008-09-10 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Brain tumor stem cell Brain tumor Neural stem cell Targeting therapy Animal Anatomy / Morphology / Histology Neurosciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Cellular and Molecular Neuroscience |
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