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| Content Provider | Springer Nature Link |
|---|---|
| Author | Daly, John W. |
| Copyright Year | 2005 |
| Abstract | 1. Acetylcholine receptors were initially defined as nicotinic or muscarinic, based on selective activation by two natural products, nicotine and muscarine. Several further nicotinic agonists have been discovered from natural sources, including cytisine, anatoxin, ferruginine, anabaseine, epibatidine, and epiquinamide. These have provided lead structures for the design of a wide range of synthetic agents.2. Natural sources have also provided competitive nicotinic antagonists, such as the Erythrina alkaloids, the tubocurarines, and methyllycaconitine. Noncompetitive antagonists, such as the histrionicotoxins, various izidines, decahydroquinolines, spiropyrrolizidine oximes, pseudophrynamines, ibogaine, strychnine, cocaine, and sparteine have come from natural sources. Finally, galanthamine, codeine, and ivermectin represent positive modulators of nicotinic function, derived from natural sources.3. Clearly, research on acetylcholine receptors and functions has been dependent on key natural products and the synthetic agents that they inspired. |
| Starting Page | 513 |
| Ending Page | 552 |
| Page Count | 40 |
| File Format | |
| ISSN | 02724340 |
| Journal | Cellular and Molecular Neurobiology |
| Volume Number | 25 |
| Issue Number | 3-4 |
| e-ISSN | 15736830 |
| Language | English |
| Publisher | Kluwer Academic Publishers-Plenum Publishers |
| Publisher Date | 2005-01-01 |
| Publisher Place | New York |
| Access Restriction | Subscribed |
| Subject Keyword | anatoxin cocaine cytisine dihydro-beta-erythroidine epibatidine epiquinamide galanthamine histrionicotoxin ibogaine methyllycaconitine muscarine nicotine noncompetitive antagonists tubocurarine Neurosciences Animal Anatomy / Morphology / Histology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Cellular and Molecular Neuroscience |
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