NDLI: Effect of microcrystal cellulose and cellulose whisker on biocompatibility of cellulose-based electrospun scaffolds

Content Provider	Springer Nature Link
Author	Jia, Baoquan Li, Yutao Yang, Bin Xiao, Di Zhang, Shengnan Rajulu, A. Varada Kondo, Tetsuo Zhang, Lina Zhou, Jinping
Copyright Year	2013
Abstract	To investigate the potential application of microcrystal cellulose (MCC) and cellulose whisker (CW) in the electrospun vascular tissue scaffolds, cellulose acetate (CA) and cellulose composite scaffolds containing MCC and CW were electrospun from CA solutions and deacetylation. Structure and morphology of MCC, CW and the fibrous composite scaffolds were investigated using FT-IR, SEM, TEM and AFM. The wettability of the scaffolds was evaluated by water contact angle analysis. The effect of MCC and CW on the biocompatibility of the scaffolds for vascular smooth muscle cells (VSMC) was assayed by MTT test, fluorescent imaging and SEM. The biocomposite scaffolds displayed multi-scaled structure and morphology. The scaffolds containing MCC and CW simultaneously exhibited significantly higher cell viability compared to those with only MCC or CW and no filler. Cell viability and morphology within the scaffolds become better with increasing content of MCC and CW. The composite scaffolds with both micro- and nano-scale organization could mimic the native extracellular matrix more closely, and further produce synergistic enhancement on VSMC viability, adhesion and proliferation. This study provides the potential applications of renewable cellulose-based particulates in biomedical field.
Starting Page	1911
Ending Page	1923
Page Count	13
File Format	PDF
ISSN	09690239
Journal	Cellulose
Volume Number	20
Issue Number	4
e-ISSN	1572882X
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-05-23
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microcrystal cellulose Cellulose whisker Biocomposite scaffold Biocompatibility Tissue engineering Bioorganic Chemistry Physical Chemistry Organic Chemistry Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Polymers and Plastics

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