NDLI: Wound debridement and antibiofilm properties of gamma-ray DMAEMA-grafted onto cotton gauzes

Content Provider	Springer Nature Link
Author	Luna Straffon, Marco A. Contreras García, Angel Brackman, Gilles Coenye, Tom Concheiro, Angel Alvarez Lorenzo, Carmen Bucio, Emilio
Copyright Year	2014
Abstract	Cotton gauze fabric was functionalized with 2-(dimethylamino)ethyl methacrylate (DMAEMA) with the aim of developing wound dressings with antibiofilm activity and tunable debriding activity. Cotton-g-DMAEMA gauzes were prepared via one-step grafting (direct method) using 60Co γ-rays as source to initiate the polymerization process. The effects of absorbed dose, dose rate, and monomer concentration on the degree of grafting were evaluated in detail. Some cotton-g-DMAEMA gauzes were subsequently quaternized with methyl iodide. Grafting of DMAEMA and sequential quaternization were confirmed by FTIR-ATR spectroscopy; thermal properties were analyzed using TGA, and morphology by scanning electron microscopy. Grafting of DMAEMA gauzes enhanced blood absorption and collagenase activity, while further quaternization led to a remarkable inhibition of the proteinase activity. Their antimicrobial features were analyzed by evaluating their biofilm inhibiting and biofilm eradicating properties in an in vitro chronic wound model. Although the non-quaternized gauzes only displayed moderate biofilm inhibitory properties at best, the quaternized cotton-g-DMAEMA bearing the highest content of DMAEMA displayed strong biofilm inhibiting and biofilm eradicating properties. This indicates that quaternized cotton-g-DMAEMA gauzes are less prone to be colonized by bacteria and can notably reduce the number of colonies in an infected wound.
Starting Page	3767
Ending Page	3779
Page Count	13
File Format	PDF
ISSN	09690239
Journal	Cellulose
Volume Number	21
Issue Number	5
e-ISSN	1572882X
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-07-30
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Poly[2-(dimethylamino)ethyl methacrylate] γ-Ray irradiation Collagenase inhibition Blood absorption Antimicrobial gauze Biofilm inhibition and eradication Bioorganic Chemistry Physical Chemistry Organic Chemistry Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Polymers and Plastics

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