NDLI: Molecular weight-dependent anticoagulation activity of sulfated cellulose derivatives

Content Provider	Springer Nature Link
Author	Wang, Zhao Mei Xiao, Kai Jun Li, Lin Wu, Jian Yong
Copyright Year	2010
Abstract	This work is to examine the molecular weight (MW)-anticoagulation activity relationship of sulfated cellulose derivatives (cellulose sulfates, CS). The initial CS with a degree of substitution (1.59) was prepared by homogeneous sulfation of microcrystalline cellulose in an ionic liquid [C4mim]Cl. It was then hydrolyzed in a dilute acidic solution and separated into four MW fractions of 59, 23, 10 × 103 g/mol and below 2.7 × 103 g/mol. The anticoagulation activities based on in vitro assays of coagulation time and coagulation factors in human plasma showed a positive correlation with the MW of CS, while the activity assay of clotting time in rats exhibited a negative correlation with the MW 10–59 × 103 g/mol, and the fraction with a MW <2.7 × 103 g/mol exhibited a more moderate and durable activity. The results indicate that MW is a major factor on the anticoagulant properties of CS derivatives and higher MW range is favorable for in vitro, and lower MW suitable for in vivo applications.
Starting Page	953
Ending Page	961
Page Count	9
File Format	PDF
ISSN	09690239
Journal	Cellulose
Volume Number	17
Issue Number	5
e-ISSN	1572882X
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-08-12
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Sulfated cellulose derivatives Acidic degradation Anticoagulation Molecular weight Ionic liquid Polymer Sciences Organic Chemistry Physical Chemistry Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Polymers and Plastics

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