NDLI: How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale

Content Provider	Springer Nature Link
Author	Han, Sungwon Lemire, Joseph Appanna, Varun P. Auger, Christopher Castonguay, Zachary Appanna, Vasu D.
Copyright Year	2013
Abstract	Metal pollutants are a global health risk due to their ability to contribute to a variety of diseases. Aluminum (Al), a ubiquitous environmental contaminant is implicated in anemia, osteomalacia, hepatic disorder, and neurological disorder. In this review, we outline how this intracellular generator of reactive oxygen species (ROS) triggers a metabolic shift towards lipogenesis in astrocytes and hepatocytes. This Al-evoked phenomenon is coupled to diminished mitochondrial activity, anerobiosis, and the channeling of α-ketoacids towards anti-oxidant defense. The resulting metabolic reconfiguration leads to fat accumulation and a reduction in ATP synthesis, characteristics that are common to numerous medical disorders. Hence, the ability of Al toxicity to create an oxidative environment promotes dysfunctional metabolic processes in astrocytes and hepatocytes. These molecular events triggered by Al-induced ROS production are the potential mediators of brain and liver disorders.
Starting Page	75
Ending Page	84
Page Count	10
File Format	PDF
ISSN	07422091
Journal	Cell Biology and Toxicology
Volume Number	29
Issue Number	2
e-ISSN	15736822
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-03-06
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Aluminum toxicity Reactive oxygen species Mitochondrial dysfunction Dyslipidemia α-ketoacids Neurological and hepatic diseases Cell Biology Pharmacology/Toxicology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Health, Toxicology and Mutagenesis Toxicology

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