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Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases

Lipopolysaccharide induces distinct alterations in the microtubule cytoskeleton of monocytes

Cell Biology and Toxicology : Volume 16, Issue 4, August 2000

Cell Biology and Toxicology : Volume 16, Issue 3, June 2000

Cell Biology and Toxicology : Volume 16, Issue 2, April 2000

Cell Biology and Toxicology : Volume 16, Issue 1, February 2000

Cell Biology and Toxicology : Volume 15

Cell Biology and Toxicology : Volume 14

Cell Biology and Toxicology : Volume 13

Lipopolysaccharide induces distinct alterations in the microtubule cytoskeleton of monocytes

Content Provider	Springer Nature Link
Author	Rußwurm, S. Böhm, K.J. Mühlig, P. Wiederhold, M. König, K. Reinhart, K.
Copyright Year	2000
Abstract	Microtubules are obligate functional elements of almost all eukaryotic cells. They are involved in a broad range of essential cellular functions and structural changes of this system may trigger cell death. Recently, we have reported that lipopolysaccharides inhibitin vitro microtubule formation due to exclusion of microtubule-associated proteins. The distinct epitopes of lipopolysaccharides responsible for these effects and thein vivo relevance of these data are unknown. Therefore, this study was conducted to elucidate the effects of lipid A, the biologically active motif of lipopolysaccharides, on microtubule formationin vitro and to prove whether lipopolysaccharides affect the microtubule architecture of cultured human monocytesin vivo. Despite a dose- and pH-dependent inhibition of microtubule formation by lipopolysaccharides, inhibition of microtubule assembly could be mimicked by lipid A. Near-infrared two-photon microscopy revealed that human peripheral blood monocytes accumulate lipopolysaccharides. A vesicular distribution pattern of lipopolysaccharides within the monocytes was observed. Confocal laser scanning microscopy demonstrated alterations in the microtubule architecture of monocytes after incubation with lipopolysaccharides. Lipid A seems to be responsible for the observed crosstalk between lipopolysaccharides and microtubule proteins. Furthermore, our data indicate that lipopolysaccharides may affect the microtubule architecture in human monocytes after intracellular accumulation directly. Therefore, we conclude, that the microtubule cytoskeleton is an essential intracellular target for sepsis-relevant bacterial components such as lipopolysaccharides.
Starting Page	339
Ending Page	346
Page Count	8
File Format	PDF
ISSN	07422091
Journal	Cell Biology and Toxicology
Volume Number	16
Issue Number	5
e-ISSN	15736822
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2000-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Health, Toxicology and Mutagenesis Toxicology

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