NDLI: Enhanced Expression of a Novel Protein in Human Cancer Cells: A Potential Aid to Cancer Diagnosis

Content Provider	Springer Nature Link
Author	Cangul, H. Salnikow, K. Yee, H. Zagzag, D. Commes, T. Costa, M.
Copyright Year	2002
Abstract	Cap43 is a protein whose RNA is induced under conditions of severe hypoxia or prolonged elevations of intracellular calcium. Cap43 protein is expressed at low levels in normal tissues; however, in a variety of cancers, including lung, brain, melanoma, liver, prostate, breast, and renal cancers, Cap43 protein is overexpressed in cancer cells. The low level of expression of Cap43 in some normal tissues compared to their cancerous counterparts combined with the high stability of Cap43 protein and mRNA makes the Cap43 gene a new, important cancer marker. We hypothesize that the mechanism of Cap43 overexpression in cancer cells involves a state of hypoxia characteristic of cancer cells where the Cap43 protein becomes a signature for this hypoxic state.
Starting Page	87
Ending Page	96
Page Count	10
File Format	PDF
ISSN	07422091
Journal	Cell Biology and Toxicology
Volume Number	18
Issue Number	2
e-ISSN	15736822
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2002-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Pharmacology/Toxicology Biochemistry Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Health, Toxicology and Mutagenesis Toxicology

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Enhanced Expression of a Novel Protein in Human Cancer Cells: A Potential Aid to Cancer Diagnosis