NDLI: Effect of sulfite treatment on total antioxidant capacity, total oxidant status, lipid hydroperoxide, and total free sulfydryl groups contents in normal and sulfite oxidase-deficient rat plasma

Content Provider	Springer Nature Link
Author	Herken, Emine Nur Kocamaz, Erdogan Erel, Ozcan Celik, Hakim Kucukatay, Vural
Copyright Year	2008
Abstract	Sulfites, which are commonly used as preservatives, are continuously formed in the body during the metabolism of sulfur-containing amino acids. Sulfite oxidase (SOX) is an essential enzyme in the pathway of the oxidative degradation of sulfite to sulfate protecting cells from sulfite toxicity. This article investigated the effect of sulfite on total antioxidant capacity (TAC), total oxidant status, lipid hydroperoxide (LOOH), and total free sulfydryl groups (–SH) levels in normal and SOX-deficient male albino rat plasma. For this purpose, rats were divided into four groups: control, sulfite-treated, SOX-deficient, and sulfite-treated SOX-deficient groups. SOX deficiency was established by feeding rats a low molybdenum diet and adding to their drinking water 200 ppm tungsten. Sulfite (70 mg/kg) was administered to the animals via their drinking water. SOX deficiency together with sulfite treatment caused a significant increase in the plasma LOOH and total oxidant status levels. –SH content of rat plasma significantly decreased by both sulfite treatment and SOX deficiency compared to the control. There was also a significant decrease in plasma TAC level by sulfite treatment. In conclusion, sulfite treatment affects the antioxidant/oxidant balance of the plasma cells of the rats toward oxidants in SOX-deficient groups.
Starting Page	355
Ending Page	362
Page Count	8
File Format	PDF
ISSN	07422091
Journal	Cell Biology and Toxicology
Volume Number	25
Issue Number	4
e-ISSN	15736822
Language	English
Publisher	Springer Netherlands
Publisher Date	2008-06-14
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Antioxidant defense Free radicals Sulfite Sulfite oxidase deficiency Biochemistry Pharmacology/Toxicology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Health, Toxicology and Mutagenesis Toxicology

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