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| Content Provider | Springer Nature Link |
|---|---|
| Author | Li, M. Kong, Z. M. Liu, Z. L. |
| Copyright Year | 2006 |
| Abstract | Eicosapentaenoic acid (EPA) is one of the major dietary polyunsaturated fatty acids and induces apoptosis in several cancer cells. In this study, the EPA induced lipid peroxidation and response of antioxidative enzymes have been investigated in rat pheochromocytoma PC12 cells to elucidate the mechanisms of apoptosis induced by the polyunsaturated fatty acid EPA. We have analyzed superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities and glutathione (GSH) contents in PC12 cells after exposure to different concentrations of EPA. Lipid peroxidation was shown to increase in the presence of EPA as an indication of the oxidative damage. Lipid peroxidation was enhanced by EPA in a dose-dependent manner, and the loss of cell viability was partially reversed by vitamin E. In the case of antioxidant enzyme activities, SOD and GPX activities and GSH contents increased significantly at 50 μmol/L EPA and were respectively 2.41-fold (p < 0.01), 3.49-fold (p < 0.05), and 1.43-fold (p < 0.05) higher than controls. The CAT activity at 10 μmol/L had the highest value and was increased by 25.83% (p < 0.05) compared to control. The results suggest that in PC12 cells the mechanism of apoptosis induced by EPA may be partly due to lipid peroxidation. |
| Starting Page | 331 |
| Ending Page | 337 |
| Page Count | 7 |
| File Format | |
| ISSN | 07422091 |
| Journal | Cell Biology and Toxicology |
| Volume Number | 22 |
| Issue Number | 5 |
| e-ISSN | 15736822 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2006-07-23 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | antioxidant enzymes eicosapentaenoic acid glutathione lipid peroxidation PC12 cells Pharmacology/Toxicology Biochemistry Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Health, Toxicology and Mutagenesis Toxicology |
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