NDLI: Lipoxygenase metabolism: roles in tumor progression and survival

Content Provider	Springer Nature Link
Author	Pidgeon, Graham P. Lysaght, Joanne Krishnamoorthy, Sriram Reylds, John V. O’Byrne, Ken Nie, Daotai Honn, Kenneth V.
Copyright Year	2007
Abstract	The metabolism of arachidonic acid through lipoxygenase pathways leads to the generation of various biologically active eicosanoids. The expression of these enzymes vary throughout the progression of various cancers, and thereby they have been shown to regulate aspects of tumor development. Substantial evidence supports a functional role for lipoxygenase-catalyzed arachidonic and linoleic acid metabolism in cancer development. Pharmacologic and natural inhibitors of lipoxygenases have been shown to suppress carcinogenesis and tumor growth in a number of experimental models. Signaling of hydro[peroxy]fatty acids following arachidonic or linoleic acid metabolism potentially effect diverse biological phenomenon regulating processes such as cell growth, cell survival, angiogenesis, cell invasion, metastatic potential and immunomodulation. However, the effects of distinct LOX isoforms differ considerably with respect to their effects on both the individual mechanisms described and the tumor being examined. 5-LOX and platelet type 12-LOX are generally considered pro-carcinogenic, with the role of 15-LOX-1 remaining controversial, while 15-LOX-2 suppresses carcinogenesis. In this review, we focus on the molecular mechanisms regulated by LOX metabolism in some of the major cancers. We discuss the effects of LOXs on tumor cell proliferation, their roles in cell cycle control and cell death induction, effects on angiogenesis, migration and the immune response, as well as the signal transduction pathways involved in these processes. Understanding the molecular mechanisms underlying the anti-tumor effect of specific, or general, LOX inhibitors may lead to the design of biologically and pharmacologically targeted therapeutic strategies inhibiting LOX isoforms and/or their biologically active metabolites, that may ultimately prove useful in the treatment of cancer, either alone or in combination with conventional therapies.
Starting Page	503
Ending Page	524
Page Count	22
File Format	PDF
ISSN	01677659
Journal	Cancer and Metastasis Reviews
Volume Number	26
Issue Number	3-4
e-ISSN	15737233
Language	English
Publisher	Springer US
Publisher Date	2007-10-18
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lipoxygenase Tumor survival Apoptosis Angiogenesis Immune suppression Cancer Research Oncology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The other side of MMPs: Protective roles in tumor progression

Improving cancer immunotherapy by targeting tumor-induced immune suppression

Tetraspanins and tumor progression

Eicosanoids and other lipid mediators and the tumor hypoxic microenvironment

Regulation of p53 by ING family members in suppression of tumor initiation and progression

Chemokines in tumor angiogenesis and metastasis

Distinct roles of DKK1 and DKK2 in tumor angiogenesis

The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis

Cyclooxygenases, prostanoids, and tumor progression

Lipoxygenase metabolism: roles in tumor progression and survival

Similar Documents

The other side of MMPs: Protective roles in tumor progression

Improving cancer immunotherapy by targeting tumor-induced immune suppression

Tetraspanins and tumor progression

Eicosanoids and other lipid mediators and the tumor hypoxic microenvironment

Regulation of p53 by ING family members in suppression of tumor initiation and progression

Chemokines in tumor angiogenesis and metastasis

Distinct roles of DKK1 and DKK2 in tumor angiogenesis

The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis

Cyclooxygenases, prostanoids, and tumor progression

Lipoxygenase metabolism: roles in tumor progression and survival