NDLI: Neutrophils: important contributors to tumor progression and metastasis

Content Provider	Springer Nature Link
Author	Swierczak, Agnieszka Mouchemore, Kellie A. Hamilton, John A. Anderson, Robin L.
Copyright Year	2015
Abstract	The presence of neutrophils in tumors has traditionally been considered to be indicative of a failed immune response against cancers. However, there is now evidence showing that neutrophils can promote tumor growth, and increasingly, the data support an active role for neutrophils in tumor progression to distant metastasis. Neutrophils have been implicated in promoting metastasis in cancer patients, where neutrophil numbers and neutrophil-related factors and functions have been associated with progressive disease. Nevertheless, the role of neutrophils in tumors, both at the primary and secondary sites, remains controversial, with some studies reporting their anti-tumor functions. This review will focus on the data demonstrating a role for neutrophils in both tumor growth and metastasis and will attempt to clarify the discrepancies in the literature.
Starting Page	735
Ending Page	751
Page Count	17
File Format	PDF
ISSN	01677659
Journal	Cancer and Metastasis Reviews
Volume Number	34
Issue Number	4
e-ISSN	15737233
Language	English
Publisher	Springer US
Publisher Date	2015-09-11
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neutrophils Cancer Metastasis Inflammation Cancer Research Oncology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Neutrophils: important contributors to tumor progression and metastasis