NDLI: Immune regulation of therapy-resistant niches: emerging targets for improving anticancer drug responses

Content Provider	Springer Nature Link
Author	Jinushi, Masahisa
Copyright Year	2014
Abstract	Emerging evidence has unveiled a critical role for immunological parameters in predicting tumor prognosis and clinical responses to anticancer therapeutics. On the other hand, responsiveness to anticancer drugs greatly modifies the repertoires, phenotypes, and immunogenicity of tumor-infiltrating immune cells, serving as a critical factor to regulate tumorigenic activities and the emergence of therapy-resistant phenotypes. Tumor-associated immune functions are influenced by distinct or overlapping sets of therapeutic modalities, such as cytotoxic chemotherapy, radiotherapy, or molecular-targeted therapy, and various anticancer modalities have unique properties to influence the mode of cross-talk between tumor cells and immune cells in tumor microenvironments. Thus, it is critical to understand precise molecular machineries whereby each anticancer strategy has a distinct or overlapping role in regulating the dynamism of reciprocal communication between tumor and immune cells in tumor microenvironments. Such an understanding will open new therapeutic opportunities by harnessing the immune system to overcome resistance to conventional anticancer drugs.
Starting Page	737
Ending Page	745
Page Count	9
File Format	PDF
ISSN	01677659
Journal	Cancer and Metastasis Reviews
Volume Number	33
Issue Number	2-3
e-ISSN	15737233
Language	English
Publisher	Springer US
Publisher Date	2014-04-23
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Anticancer drug resistance Intratumor immune response Chemotherapy Radiotherapy Molecular targeting Cancer Research Oncology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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