NDLI: Melanoma and lifetime UV radiation

Content Provider	Springer Nature Link
Author	Solomon, Cam C. White, Emily Kristal, Alan R. Vaughan, Thomas
Copyright Year	2004
Abstract	ObjectiveBecause most risk factors for melanoma are immutable constitutional factors such as skin type, it is important to more fully understand the relationship between melanoma risk and sun exposure, one of the few modifiable risk factors for the disease. The goal of this case–control study was to quantify the risks of melanoma associated with UV exposure at different periods of life. Methods: Cases were 386 patients between the ages of 35 and 74 who were diagnosed with primary cutaneous melanoma within the Seattle–Puget Sound area during 1997. Controls were 727 participants of the same age and geographic area, selected by random-digit dialing. A telephone interview included a complete residential history, lifetime sun exposure history (days in the summer sun for at least 4h at each place of residence), and personal characteristics. UV exposure was calculated based on satellite data on potential erythemal exposure at each place of residence, years at each location and time spent in the sun at each location. Logistic regression was used to estimate odds ratios (OR) and 95 confidence intervals (CI) reflecting the risk of melanoma associated with UV exposure, after adjustment for age, sex, income, tendency to burn and sunburns during ages 2–10. Results: Among women, lifetime UV exposure was associated with melanoma risk (adjusted OR=1.99 for highest versus lowest quartile, 95 CI: 0.95–3.03, p for trend=0.008). There were significant trends for UV exposure during ages 1–10, 11–20 and 31–40 (all p<0.02). Among men, there were no significant associations at any time period, but lifetime UV exposure was associated with higher risk for men who had a tendency toward severe or painful sunburns (OR= 2.85 for highest versus lowest quartile, 95 CI: 0.84–9.64, p for trend=0.04). Conclusion: The differing results by sex are not easily interpretable, though it may be useful to target those with a higher sensitivity to the sun when formulating messages for prevention of melanoma by lowering exposure to UV.
Starting Page	893
Ending Page	902
Page Count	10
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	15
Issue Number	9
e-ISSN	15737225
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2004-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	melanoma sunlight residence Public Health/Gesundheitswesen Hematology Oncology Epidemiology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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