NDLI: Reproductive factors, adiposity, breastfeeding and their associations with ovarian cancer in an Asian cohort

Content Provider	Springer Nature Link
Author	Gay, Gibson Ming Wei Lim, Jane Shu Ping Chay, Wen Yee Chow, Khuan Yew Tan, Min Han Lim, Wei Yen
Copyright Year	2015
Abstract	The aim of this study was to assess associations of breastfeeding, adiposity and reproductive risk factors with ovarian cancer risk in a Singaporean population. In addition to the main analysis, interaction effects of parity on other risk factors were examined.A retrospective cohort consisting of 28,201 women with 107 incident ovarian cancers in up to 17 years of follow-up from the Singapore Breast Cancer Screening Project (1994–1997) was studied. Hazard ratios (HRs) for risk factors were estimated using Cox proportional hazards models.Body mass index and breastfeeding were found to have no statistical significant association with ovarian cancer risk. Gravidity was inversely associated with ovarian cancer risk [each pregnancy, adjusted HR 0.89, 95 % confidence interval (CI) 0.81, 0.97], while results for parity were very similar (per delivery, HR 0.89, 95 % CI 0.81, 0.98). Each additional year of ovulatory period was found to increase ovarian cancer risk by 2 % (HR 1.02, 95 % CI 1.00, 1.04). Each year increase in total duration of oral contraceptive use reduced ovarian cancer risk by 6 % (HR 0.94, 95 % CI 0.85, 1.02).Parity, gravidity and shorter ovulatory period were associated with lower ovarian cancer risk. Breastfeeding and body mass index were not associated with ovarian cancer risk, while increased duration of oral contraceptive use resulted in borderline risk reduction. No significant evidence was found to suggest that parity had an interaction effect on any risk factor.
Starting Page	1561
Ending Page	1573
Page Count	13
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	26
Issue Number	11
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-09-05
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Asian Breastfeeding Obesity Ovarian cancer Reproductive factors Risk factors Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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