NDLI: Androgen deprivation therapy and the risk of colorectal cancer in patients with prostate cancer

Content Provider	Springer Nature Link
Author	Assayag, Jonathan Yin, Hui Benayoun, Serge Pollak, Michael N. Suissa, Samy Azoulay, Laurent
Copyright Year	2013
Abstract	Androgens are known to play an important protective role on colorectal carcinogenesis, and thus the objective of this study was to determine whether androgen deprivation therapy (ADT) is associated with an increased risk of incident colorectal cancer in patients with prostate cancer.We conducted a population-based cohort study within the UK General Practice Research Database population which included all patients newly diagnosed with prostate cancer between 1 January 1988 and 31 December 2008, followed until 31 December 2009. Time-dependent Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) of incident primary colorectal cancer associated with the use of ADT. Secondary analyses considered cumulative duration of use and specific ADTs.The cohort included a total of 21,503 patients, of whom 184 were diagnosed with colorectal cancer during a mean (SD) follow-up 4.0 (3.0) years (rate 2.4/1,000 person-years). Overall, use of ADT was not associated with an increased risk of colorectal cancer (HR 0.99, 95 % CI 0.73–1.35). Similarly, no association was observed in terms of duration use, although this secondary analysis may have been limited by statistical power. With respect to specific ADTs, bilateral orchiectomy was the only therapy associated with an increased risk of colorectal cancer (HR 2.50, 95 % CI 1.13–5.52).Overall, the use of ADT is not associated with an increased risk of incident colorectal cancer. The increased risk observed with bilateral orchiectomy may possibly be due to the prolonged androgen suppression of this therapy.
Starting Page	839
Ending Page	845
Page Count	7
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	24
Issue Number	5
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-04-02
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Androgen deprivation therapy Colorectal cancer Prostate cancer Population based Safety Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Bisphenol A may reduce the efficacy of androgen deprivation therapy in prostate cancer

Risk of ischemic stroke in patients with prostate cancer receiving androgen deprivation therapy in Taiwan

Risk of fracture in men with prostate cancer on androgen deprivation therapy: a population-based cohort study in New Zealand

Type 2 diabetes and the risk of mortality among patients with prostate cancer

The effect of warfarin therapy on breast, colorectal, lung, and prostate cancer survival: a population-based cohort study using the Clinical Practice Research Datalink

Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Metformin use and prostate cancer in Caucasian men: results from a population-based case–control study

Statins and colorectal cancer risk: a longitudinal study

Boron intake and prostate cancer risk

Androgen deprivation therapy and the risk of colorectal cancer in patients with prostate cancer

Similar Documents

Bisphenol A may reduce the efficacy of androgen deprivation therapy in prostate cancer

Risk of ischemic stroke in patients with prostate cancer receiving androgen deprivation therapy in Taiwan

Risk of fracture in men with prostate cancer on androgen deprivation therapy: a population-based cohort study in New Zealand

Type 2 diabetes and the risk of mortality among patients with prostate cancer

The effect of warfarin therapy on breast, colorectal, lung, and prostate cancer survival: a population-based cohort study using the Clinical Practice Research Datalink

Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Metformin use and prostate cancer in Caucasian men: results from a population-based case–control study

Statins and colorectal cancer risk: a longitudinal study

Boron intake and prostate cancer risk

Androgen deprivation therapy and the risk of colorectal cancer in patients with prostate cancer