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| Content Provider | Springer Nature Link |
|---|---|
| Author | Figueiredo, Jane C. Levine, A. Joan Lee, Won H. Conti, David V. Poynter, Jenny N. Campbell, Peter T. Duggan, David Lewinger, Juan Pablo Martinez, Maria Elena Ulrich, Cornelia M. Newcomb, Polly Potter, John Limburg, Paul J. Hopper, John Jenkins, Mark A. Marchand, Loic Baron, John A. Haile, Robert W. |
| Copyright Year | 2009 |
| Abstract | Folate status is an important predictor of colorectal cancer risk. Common genetic variants in genes involved in regulating cellular folate levels might also predict risk, but there are limited data on this issue. We conducted a family-based case–control association study of variants in four genes involved in folate uptake and distribution: FOLR1, FPGS, GGH and SLC19A1, using 1,750 population-based and 245 clinic-based cases of pathologically confirmed colorectal cancer and their unaffected relatives participating in the Colon Cancer Family Registries. Standardized questionnaires, administered to all participants, collected information on risk factors and diet. Standard molecular techniques were used to determine microsatellite instability (MSI) status on cases. tagSNPs (n = 29) were selected based on coverage as assessed by pairwise r 2. We found no evidence that tagSNPs in these genes were associated with risk of colorectal cancer. For the SLC19A1-rs1051266 (G80A, Arg27His) missense polymorphism, the A/A genotype was not associated with risk of colorectal cancer using population-based (OR = 1.00; 95% CI = 0.81–1.23) or clinic-based (OR = 0.75; 95% CI = 0.44–1.29) families compared to the G/A and G/G genotypes. We found no evidence that the association between any tagSNP and CRC risk was modified by multivitamin use, folic acid use and dietary folate intake and total folate intake. The odds ratios were similar, irrespective of MSI status, tumor subsite and family history of colorectal cancer. In conclusion, we found no significant evidence that genetic variants in FOLR1, GGH, FPGS and SLC19A1 are associated with the risk of colorectal cancer. |
| Starting Page | 597 |
| Ending Page | 608 |
| Page Count | 12 |
| File Format | |
| ISSN | 09575243 |
| Journal | Cancer Causes & Control |
| Volume Number | 21 |
| Issue Number | 4 |
| e-ISSN | 15737225 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2009-12-27 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Folate Folate receptor 1 (FOLR1) Solute carrier family 19 (SLC19A1) Reduced folate carrier (RFC) Folylpolyglutamate synthase (FPGS) Gamma-glutamyl hydrolase (GGH) Family-based Population-based Clinic-based Polymorphisms Colorectal cancer Case–control Hematology Epidemiology Public Health/Gesundheitswesen Oncology Biomedicine general Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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