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| Content Provider | Springer Nature Link |
|---|---|
| Author | Kato, Ikuko Canzian, Federico Franceschi, Silvia Plummer, Martyn Doorn, Leen Jan Lu, Yanhui Gioia Patricola, Lydie Vivas, Jorge Lopez, Gladys Severson, Richard K. Schwartz, Ann G. Muñoz, Nubia |
| Copyright Year | 2006 |
| Abstract | The aim of the study was to assess the effects of genetic polymorphisms in anti-inflammatory mediators, i.e., IL10, IL4 and IL4R on the prevalence of gastric precancerous lesions and their interactions with other environmental factors.The study population consisted of 2,033 Venezuelan subjects known to have extremely high Helicobacter Pylori (HP) infection rates. The odds ratios (OR) and 95% confidence intervals (CI) associated with these polymorphisms were estimated by multinominal logistic regression models for gastric precursor lesions.We found a 60% increase in risk of intestinal metaplasia (IM) and dysplasia combined (OR 1.62, 95% CI: 1.10–2.38) among the carriers of the IL10-1082 low activity allele. This increased risk was more pronounced for dysplasia than for IM. On the other hand, homozygotes with the low activity allele of the A398G polymorphism in the IL4R gene had a modest increase in risk of atrophic gastritis (OR = 1.52, 95% CI: 1.05–2.21), compared with homozygotes of the high activity allele. There were no statistically significant synergetic interactions between these polymorphisms and environmental risk factors (low fruit intake, high starchy vegetable intake and cigarette smoking) for these lesions.While the results of the present study suggest roles of genetic variability in these anti-inflammatory mediators in different stages of gastric carcinogenesis, there is high likelihood that they were chance findings due to multiple comparisons. |
| Starting Page | 1183 |
| Ending Page | 1191 |
| Page Count | 9 |
| File Format | |
| ISSN | 09575243 |
| Journal | Cancer Causes & Control |
| Volume Number | 17 |
| Issue Number | 9 |
| e-ISSN | 15737225 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2006-01-01 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Genetic polymorphisms Stomach cancer Premalignant lesions Helicobacter pylori Anti-inflammatory cytokines Cancer Research Public Health/Gesundheitswesen Hematology Oncology Epidemiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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