NDLI: Ethylene oxide and breast cancer incidence in a cohort study of 7576 women (United States)

Content Provider	Springer Nature Link
Author	Steenland, Kyle Whelan, Elizabeth Deddens, James Stayner, Leslie Ward, Elizabeth
Copyright Year	2003
Abstract	Background: Ethylene oxide (ETO) is a sterilant gas considered to be a human carcinogen, due primarily to excess hematopoietic cancer in exposed cohorts. ETO causes mammary tumors in mice, and has been associated with breast cancer incidence in one small epidemiologic study. Methods: We have studied breast cancer incidence in a cohort of 7576 women employed for at least one year and exposed for an average 10.7 years while working in commercial sterilization facilities. Breast cancer incidence (n = 319) was ascertained via interview, death certificates, cancer registries, and medical records. Interviews were obtained for 68% of the cohort. Results: The standardized incidence ratio (SIR) for incident breast cancer in the whole cohort using external referent rates (SEER) was 0.87 (0.77–0.97). The SIR for those in the top quintile of cumulative exposure, with a 15 year lag, was 1.27 (0.94–1.69), with a positive trend of increasing SIR with increasing exposure (p = 0.002). SIRs are under-estimated because breast cancer incidence in the whole cohort was under-ascertained, due to incomplete response and lack of complete coverage by state cancer registries. In internal nested case–control analyses of those with interviews (complete cancer ascertainment), controlling for reproductive risk factors, a positive exposure–response was found with the log of cumulative exposure with a 15-year lag (p = 0.0005). The odds ratio by quintile of cumulative exposure were 1.00 (0 exposure due to 15 year lag), 1.06, 0.99, 1.24, 1.42, and 1.87. Conclusions: Our data suggest that ETO is associated with breast cancer, but a causal interpretation is weakened due to some inconsistencies in exposure–response trends and possible biases due to non-response and incomplete cancer ascertainment.
Starting Page	531
Ending Page	539
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	14
Issue Number	6
e-ISSN	15737225
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2003-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Public Health/Gesundheitswesen Hematology Oncology Epidemiology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Dietary catechins and cancer incidence among postmenopausal women: the Iowa Women's Health Study (United States)

Anthropometric predictors of breast cancer incidence and survival in a multi-ethnic cohort of female residents of Hawaii, United States

Incidences and Trends of Second Cancers in Female Breast Cancer Patients: A Fixed Inception Cohort-based Analysis (United States)

Breast cancer screening practices among women in the United States, 2000

Allergy and risk of breast cancer among young women (United States)

Cigarette smoking and breast cancer risk among young women (United States)

Breast cancers among very young premenopausal women (United States)

Evaluating local differences in breast cancer incidence rates: A census-based methodology (United States)

Fertility Problems and Breast Cancer Risk in Young Women: a Case-Control Study in the United States

Ethylene oxide and breast cancer incidence in a cohort study of 7576 women (United States)

Similar Documents

Dietary catechins and cancer incidence among postmenopausal women: the Iowa Women's Health Study (United States)

Anthropometric predictors of breast cancer incidence and survival in a multi-ethnic cohort of female residents of Hawaii, United States

Incidences and Trends of Second Cancers in Female Breast Cancer Patients: A Fixed Inception Cohort-based Analysis (United States)

Breast cancer screening practices among women in the United States, 2000

Allergy and risk of breast cancer among young women (United States)

Cigarette smoking and breast cancer risk among young women (United States)

Breast cancers among very young premenopausal women (United States)

Evaluating local differences in breast cancer incidence rates: A census-based methodology (United States)

Fertility Problems and Breast Cancer Risk in Young Women: a Case-Control Study in the United States

Ethylene oxide and breast cancer incidence in a cohort study of 7576 women (United States)