NDLI: Toenail iron, genetic determinants of iron status, and the risk of glioma

Content Provider	Springer Nature Link
Author	Anic, Gabriella M. Madden, Melissa H. Thompson, Reid C. Nabors, L. Burton Olson, Jeffrey J. LaRocca, Renato V. Browning, James E. Brockman, John D. Forsyth, Peter A. Egan, Kathleen M.
Copyright Year	2013
Abstract	Iron is essential for oxygen transport and oxidative metabolism; however, elevated iron stores can trigger overproduction of reactive oxygen species and induce DNA damage. Little is known about the association between body iron stores and glioma risk. This study examined the associations of iron levels measured in toenails and genetic variants linked to body iron stores with risk of glioma in a clinic-based case–control study. Samples were collected a median of 24 days following glioma diagnosis in the cases (10th–90th percentile, range: 10–44 days). Nail iron levels were measured in 300 cases and 300 controls using neutron activation analysis. A total of 24 genetic variants associated with iron status were genotyped in 622 cases and 628 controls. Logistic regression was used to estimate odds ratios (OR) and 95 % confidence intervals (CI) for glioma risk according to toenail iron and the examined genotypes.No association was observed between toenail iron and glioma risk when restricting to cases with nails collected within ~3 weeks of diagnosis (OR = 0.93; 95 % CI 0.46, 1.87 comparing those with high (≥14 μg/g) vs. low (<6 μg/g) iron levels). In contrast, an inverse association with increasing iron was observed after restricting to cases with a delay of 3 weeks or greater (OR = 0.42; 95 % CI 0.19, 0.95), reflecting potentially insidious effects of advancing disease on iron levels among the cases. No associations were observed for any of the examined genetic variants.The results do not support a role for body iron stores as a determinant of glioma risk.
Starting Page	2051
Ending Page	2058
Page Count	8
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	24
Issue Number	12
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-08-31
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Glioma Iron Single-nucleotide polymorphism Case–control Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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