NDLI: Methyl bromide exposure and cancer risk in the Agricultural Health Study

Content Provider	Springer Nature Link
Author	Barry, Kathryn Hughes Koutros, Stella Lubin, Jay H. Coble, Joseph B. Barone Adesi, Francesco Beane Freeman, Laura E. Sandler, Dale P. Hoppin, Jane A. Ma, Xiaomei Zheng, Tongzhang Alavanja, Michael C. R.
Copyright Year	2012
Abstract	Methyl bromide is a genotoxic soil fumigant with high acute toxicity, but unknown human carcinogenicity. Although many countries have reduced methyl bromide use because of its ozone depleting properties, some uses remain in the United States and other countries, warranting further investigation of human health effects.We used Poisson regression to calculate rate ratios (RR) and 95 % confidence intervals (CI) for associations between methyl bromide use and all cancers combined, as well as 12 specific sites, among 53,588 Agricultural Health Study pesticide applicators with follow-up from 1993 to 2007. We also evaluated interactions with a family history for four common cancers (prostate, lung, colon, and lymphohematopoietic). We categorized methyl bromide exposure based on lifetime days applied weighted by an intensity score.A total of 7,814 applicators (14.6 %) used methyl bromide, predominantly before enrollment. Based on 15 exposed cases, stomach cancer risk increased monotonically with increasing methyl bromide use (RR = 1.42; 95 % CI, 0.51–3.95 and RR = 3.13; 95 % CI, 1.25–7.80 for low and high use compared with no use; p trend = 0.02). No other sites displayed a significant monotonic pattern. Although we previously observed an association with prostate cancer (follow-up through 1999), the association did not persist with longer follow-up. We observed a nonsignificant elevated risk of prostate cancer with methyl bromide use among those with a family history of prostate cancer, but the interaction with a family history did not achieve statistical significance.Our results provide little evidence of methyl bromide associations with cancer risk for most sites examined; however, we observed a significant exposure-dependent increase in stomach cancer risk. Small numbers of exposed cases and declining methyl bromide use might have influenced our findings. Further study is needed in more recently exposed populations to expand on these results.
Starting Page	807
Ending Page	818
Page Count	12
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	23
Issue Number	6
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-04-24
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Methyl bromide Fumigant Pesticide Cancer Cancer Research Hematology Epidemiology Public Health/Gesundheitswesen Oncology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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