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C-peptide, IGF-I, sex-steroid hormones and adiposity: a cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC)

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C-peptide, IGF-I, sex-steroid hormones and adiposity: a cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC)

Content Provider	Springer Nature Link
Author	Bezemer, Irene D. Rinaldi, Sabina Dossus, Laure Gils, Carla H. van. Peeters, Petra H. M. ord, Paulus A. H. van. Bue de Mesquita, H. Bas Johnsen, Soren Paaske Overvad, Kim Olsen, Anja Tjønneland, Anne Boeing, Heiner Lahmann, Petra H. Linseisen, Jakob Nagel, Gabriele Allen, Naomi Roddam, Andrew Bingham, Sheila Khaw, Kay Tee Kesse, Emmanuelle Téhard, Bertrand Clavel Chapelon, Françoise Agudo, Antonio Ardanaz, Eva Quiros, J. R. Amia, Pilar Tormo, M. J. Pala, Valeria Panico, Salvatore Vineis, Paolo Palli, Domenico Tumi, Rosario Trichopoulou, Antonia Baibas, N. Zilis, D. Hémon, Bertrand rat, Teresa Riboli, Elio Kaaks, Rudolf
Copyright Year	2005
Abstract	Objectives: The risk of some cancers is positively associated with body weight, which may influence circulating levels of sex-steroid hormones, insulin and IGF-I. Interrelationships between these hormones and the associations with adiposity were evaluated in healthy women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC).Methods: A cross-sectional analysis was performed on anthropometric and hormonal data from 743 pre- and 1217 postmenopausal women. Body mass index (BMI) and waist circumference were used as indicators of adiposity. C-peptide, Insulin Growth Factor (IGF)-I, Insulin Growth Factor binding protein (IGFBP)-3, androgens, estrogens and sex hormone binding globulin (SHBG) were measured by immunoassays; free sex steroid concentrations were calculated.Results: BMI and waist circumference were positively correlated with estrogens in postmenopausal women and with C-peptide, free testosterone and inversely with SHBG in all women. C-peptide and IGF-I were inversely correlated with SHBG, and positively with free sex steroids in postmenopausal women. IGF-I was positively associated with postmenopausal estrogens and androgen concentrations in all women.Conclusions: Sex-steroid concentrations appear to be regulated along several axes. Adiposity correlated directly with estrogens in postmenopausal women and with insulin, resulting in lower SHBG and increased levels of free sex steroids. Independent of adiposity and insulin, IGF-I was associated with decreased SHBG levels, and increased concentrations of androgens and postmenopausal estrogens.
Starting Page	561
Ending Page	572
Page Count	12
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	16
Issue Number	5
e-ISSN	15737225
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2005-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	anthropometry sex-steroid hormones insulin IGF-I Cancer Research Public Health/Gesundheitswesen Hematology Oncology Epidemiology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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