NDLI: Alcohol intake and invasive breast cancer risk by molecular subtype and race in the Carolina Breast Cancer Study

Content Provider	Springer Nature Link
Author	Williams, Lindsay A. Olshan, Andrew F. Tse, Chui Kit Bell, Mary Elizabeth Troester, Melissa A.
Copyright Year	2015
Abstract	Alcohol is an established breast cancer risk factor, but there is little evidence on whether the association differs between African Americans and whites.Invasive breast cancers (n = 1,795; 1,014 white, 781 African American) and age- and race-matched controls (n = 1,558; 844 white, 714 African American) from the Carolina Breast Cancer Study (Phases I–II) were used to estimate odds ratios (ORs) and 95 % confidence interval (CI) for pre-diagnosis drinks per week and breast cancer risk.African American controls reported lower alcohol intake than white controls across all age groups. Light drinking (0 to ≤2 per week) was more prevalent among African American controls. Moderate-to-heavy drinking was more prevalent in white controls. African Americans who reported drinking >7 drinks per week had an elevated risk compared to light drinkers [adjusted OR, 95% CI 1.62 (1.03–2.54)]. A weaker association was observed among whites [adjusted OR, 95% CI 1.20 (0.87–1.67)]. The association of >7 drinks per week with estrogen receptor-negative [adjusted OR, 95% CI 2.17 (1.25–3.75)] and triple-negative [adjusted OR, 95% CI 2.12 (1.12–4.04)] breast cancers was significant for African American, but not white women. We observed significantly elevated ORs for heavy intake at ages <25 and >50 years of age for African American women only. We found no evidence of statistical interaction between alcohol intake and oral contraceptive use or smoking.Drinking more than seven alcoholic beverages per week increased invasive breast cancer risk among white and African American women, with significant increases only among African American women. Genetic or environmental factors that differ by race may mediate the alcohol–breast cancer risk association.
Starting Page	259
Ending Page	269
Page Count	11
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	27
Issue Number	2
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-12-24
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Breast Cancer Alcohol drinking Race Subtype Epidemiology Cancer Research Biomedicine general Oncology Public Health Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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