NDLI: Maternal and birth characteristics and childhood rhabdomyosarcoma: a report from the Children’s Oncology Group

Content Provider	Springer Nature Link
Author	Lupo, Philip J. Danysh, Heather E. Skapek, Stephen X. Hawkins, Douglas S. Spector, Logan G. Zhou, Renke Okcu, M. Fatih Papworth, Karin Erhardt, Erik B. Grufferman, Seymour
Copyright Year	2014
Abstract	Previous assessments of childhood rhabdomyosarcoma have indicated maternal and birth characteristics may be associated with tumor development; however, much work remains to identify novel and confirm suspected risk factors. Our objective was to evaluate the associations between maternal and birth characteristics and childhood rhabdomyosarcoma.This case–control study included 322 cases and 322 pair-matched controls. Cases were enrolled in a trial run by the Intergroup Rhabdomyosarcoma Study Group. Population-based controls were identified using random digit dialing and were individually matched to cases on race, sex, and age. Families of the case and control subjects participated in a telephone interview, which captured information on maternal characteristics (birth control use, number of prenatal visits, anemia, and abnormal bleeding during pregnancy) and birth characteristics [birth weight, preterm birth, and type of delivery (vaginal vs. cesarean)]. Conditional logistic regression models were used to calculate an odds ratio (OR) and 95 % confidence interval (CI) for each exposure, adjusted for age, race, sex, household income, and parental education. As the two most common histologic types of rhabdomyosarcoma are embryonal (n = 215) and alveolar (n = 66), we evaluated effect heterogeneity of these exposures.The only characteristic that was associated with childhood rhabdomyosarcoma, and statistically significant, was abnormal vaginal bleeding during pregnancy (OR 1.75, 95 % CI 1.12–2.74). Birth control use (OR 1.45, 95 % CI 0.96–2.18), anemia during pregnancy (OR 1.27, 95 % CI 0.81–1.99), and preterm birth (OR 2.51, 95 % CI 0.74–8.49) were positively associated with childhood rhabdomyosarcoma, but were not statistically significant. Low birth weight [adjusted odds ratios (aOR) 4.46, 95 % CI 1.41–14.1] and high birth weight (aOR 2.41, 95 % CI 1.09–5.35) were strongly associated with alveolar rhabdomyosarcoma. However, these factors did not display significant effect heterogeneity between histologic types (p > 0.15 for all characteristics).Overall, we found little evidence that these maternal and birth characteristics are strongly associated with childhood rhabdomyosarcoma.
Starting Page	905
Ending Page	913
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	25
Issue Number	7
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2014-05-16
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Abnormal vaginal bleeding Epidemiology Rhabdomyosarcoma Soft tissue sarcoma Cancer Research Biomedicine general Oncology Public Health Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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