NDLI: Body Mass Index and Risk of Colorectal Cancer in Women (United States)

Content Provider	Springer Nature Link
Author	Lin, Jennifer Zhang, Shumin M. Cook, Nancy R. Rexrode, Kathryn M. Lee, I Min Buring, Julie E.
Copyright Year	2004
Abstract	Objective: Epidemiologic data relating obesity to risk of colorectal cancer in women have been inconclusive. Two recent studies have suggested that the association may be modified by estrogen status; BMI was positively associated with colorectal cancer risk among women with high estrogen exposures [premenopausal women, and postmenopausal women who currently received postmenopausal hormone therapy (PMH)]. We prospectively investigated the role of BMI in colorectal cancer risk along with the modifying effects of estrogen in a large cohort from the Women's Health Study. Methods: Among 39,876 apparently healthy women aged ≥45 years at baseline (54% of them were postmenopausal), 37,671 were eligible for the present study. During an average of 8.7 years of follow-up, 202 women had a confirmed diagnosis of colorectal cancer. Baseline BMI was calculated by dividing self-reported weight in kilograms by height in meters squared. Results: The multivariate relative risks (RRs) and 95% confidence interval (CI) of colorectal cancer were 1.72 (1.12–2.66) for 27–29.9 kg/m2, and 1.67 (1.08–2.59) for ≥30 kg/m2, as compared with BMI < 23 kg/m2(p for trend = 0.02). This positive association was seen primarily in the proximal colon (p for trend = 0.004). When the association was further examined according to PMH use among postmenopausal women, we found that both current and never users with higher BMI were at a greater risk of colorectal cancer (p for interaction between BMI and PMH use = 0.33). As compared with BMI <23 kg/m2, the multivariate RRs and 95% CI for 27–29.9 and ≥30 kg/m2 were 1.98 (0.98–3.99) and 1.41 (0.65–3.06) among current users, and 1.05 (0.42–2.65) and 2.91 (1.40–6.06) among never users. Conclusions: These data suggest that higher BMI was associated with an elevated risk of colorectal cancer, and the positive relationship was not altered by estrogen exposure among postmenopausal women.
Starting Page	581
Ending Page	589
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	15
Issue Number	6
e-ISSN	15737225
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2004-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Public Health/Gesundheitswesen Hematology Oncology Epidemiology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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