NDLI: Spatial clustering of leukemia and type 1 diabetes in children in Denmark

Content Provider	Springer Nature Link
Author	Schmiedel, Sven Jacquez, Geoffrey M. Blettner, Maria Schüz, Joachim
Copyright Year	2011
Abstract	It has been proposed that type 1 diabetes (T1D) and leukemia in children may cluster in space and time due to common spatially mediated etiologies. We investigated this hypothesis and clustering of both diseases separately in Danish children aged 0–14 years, using 1,168 leukemia cases diagnosed in the period 1980–2006, 2,443 T1D cases diagnosed 1996–2006, and population-based controls matched on age, gender, and time of diagnosis. Residential histories from birth to diagnosis were collected. For leukemia in ages 0–14 years, we found no evidence of clustering; we did find spatial clustering at time of diagnosis for children aged 2–6 years with acute lymphoblastic leukemia (ALL) (observed/expected [95% confidence interval]: 1.35 [1.15–1.54]). T1D cases showed clustering at birth for ages 0–14 years; for ages 0–4 years at diagnosis, and when the residential history was accounted for. T1D cases clustered near leukemia cases particularly in the age group 2–6 years at diagnosis. Leukemia and T1D in this age group thus may share etiological factors mediated by geographic location. This suggests common environmental risk factors, with exposure to infections as first possible candidate, geographically localized exposure to agents that compromise development and/or response of the immune system being a second, and chance being a third.
Starting Page	849
Ending Page	857
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	22
Issue Number	6
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-03-25
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Clustering Leukemia Diabetes Children Denmark Public Health/Gesundheitswesen Oncology Biomedicine general Cancer Research Hematology Epidemiology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Trends in adult leukemia incidence and survival in Denmark, 1943–2003

Questionable evidence of increasing incidence of invasive penile cancer in Denmark

Breast cancer incidence and use of hormone therapy in Denmark 1978–2007

Questionable evidence of increasing incidence of invasive penile cancer in Denmark: authors reply

Authors’ reply

Prostate cancer screening

Cancer causes & control

Chronic lymphocytic leukemia radiogenicity: a systematic review

Leukemia survival in children, adolescents, and young adults: influence of socioeconomic status and other demographic factors

Spatial clustering of leukemia and type 1 diabetes in children in Denmark

Similar Documents

Trends in adult leukemia incidence and survival in Denmark, 1943–2003

Questionable evidence of increasing incidence of invasive penile cancer in Denmark

Breast cancer incidence and use of hormone therapy in Denmark 1978–2007

Questionable evidence of increasing incidence of invasive penile cancer in Denmark: authors reply

Authors’ reply

Prostate cancer screening

Cancer causes & control

Chronic lymphocytic leukemia radiogenicity: a systematic review

Leukemia survival in children, adolescents, and young adults: influence of socioeconomic status and other demographic factors

Spatial clustering of leukemia and type 1 diabetes in children in Denmark