NDLI: Metalworking fluid exposure and cancer risk in a retrospective cohort of female autoworkers

Content Provider	Springer Nature Link
Author	Friesen, Melissa C. Betenia, Nicole Costello, Sadie Eisen, Ellen A.
Copyright Year	2012
Abstract	Metalworking fluids (MWFs) have been associated with cancer of several sites, but the risks have been primarily examined in men or in studies that adjusted for gender in analyses. To evaluate whether risks were similar in women, we report cancer mortality risk among 4,825 female autoworkers within the united autoworkers–general motors autoworkers cohort.Standardized mortality rates (SMRs) were calculated based on Michigan death rates (1980–2004). Internal comparisons (1941–2004) were examined using Cox regression for straight, soluble, and synthetic MWFs, and their corresponding oil- and water-based fractions.MWF exposure levels in the female cohort were generally less than two-third the MWF levels in the male cohort. Female autoworkers had an excess of cancer from all sites (SMR, 1.10; 95 % confidence interval (CI), 0.98–1.22) and lung cancer (SMR, 2.08; 95 % CI, 1.71–2.52). Colon cancer risk increased with straight (mineral oil) MWF exposure (exposure > median; hazard ratio = 3.1; 95 % CI, 1.2–8.0). A protective effect was observed for ovarian cancer with the soluble MWFs and water-based MWF metrics. Although bladder, rectal, and laryngeal cancers and malignant melanoma have been associated with straight MWF exposure and pancreatic cancer with synthetic MWF in men, there were too few deaths in this female subcohort to examine exposure–response relations for these sites. Results were null for lung and breast cancer.Our findings support an association between colon cancer and straight MWFs, but we found limited evidence of risk for other tumor sites at the lower exposure levels experienced by the female autoworkers.
Starting Page	1075
Ending Page	1082
Page Count	8
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	23
Issue Number	7
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-05-05
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Metalworking fluids Cancer mortality Colon cancer Women’s health Cohort studies Hematology Biomedicine general Epidemiology Public Health/Gesundheitswesen Oncology Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Metalworking fluid exposure and cancer risk in a retrospective cohort of female autoworkers

Serum calcium and the risk of prostate cancer

Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer

Fruit and vegetable intake and risk of cancer in the Swedish women’s lifestyle and health cohort

Physical activity, sedentary behavior, and the risk of colon and rectal cancer in the NIH-AARP Diet and Health Study

Serum uric acid and risk of cancer mortality in a large prospective male cohort

Bladder cancer mortality trends and patterns in Córdoba, Argentina (1986–2006)

Coffee and caffeine intake and the risk of ovarian cancer: the Iowa Women’s Health Study

Association between psoriasis and incident cancer: the Iowa’s Women’s Health Study

Metalworking fluid exposure and cancer risk in a retrospective cohort of female autoworkers

Similar Documents

Metalworking fluid exposure and cancer risk in a retrospective cohort of female autoworkers

Serum calcium and the risk of prostate cancer

Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer

Fruit and vegetable intake and risk of cancer in the Swedish women’s lifestyle and health cohort

Physical activity, sedentary behavior, and the risk of colon and rectal cancer in the NIH-AARP Diet and Health Study

Serum uric acid and risk of cancer mortality in a large prospective male cohort

Bladder cancer mortality trends and patterns in Córdoba, Argentina (1986–2006)

Coffee and caffeine intake and the risk of ovarian cancer: the Iowa Women’s Health Study

Association between psoriasis and incident cancer: the Iowa’s Women’s Health Study

Metalworking fluid exposure and cancer risk in a retrospective cohort of female autoworkers