NDLI: Intake of fruit and vegetables and risk of bladder cancer: a dose–response meta-analysis of observational studies

Content Provider	Springer Nature Link
Author	Yao, Baodong Yan, Yujie Ye, Xianwu Fang, Hong Xu, Huilin Liu, Yinan Li, Sheran Zhao, Yanping
Copyright Year	2014
Abstract	Observational studies suggest an association between fruit and vegetables intake and risk of bladder cancer, but the results are controversial.We therefore summarized the evidence from observational studies in categorical, linear, and nonlinear, dose–response meta-analysis. Pertinent studies were identified by searching EMBASE and PubMed from their inception to August 2013.Thirty-one observational studies involving 12,610 cases and 1,121,649 participants were included. The combined rate ratio (RR, 95 % CI) of bladder cancer for the highest versus lowest intake was 0.83 (0.69–0.99) for total fruit and vegetables, 0.81 (0.70–0.93) for total vegetables, 0.77 (0.69–0.87) for total fruit, 0.84 (0.77–0.91) for cruciferous vegetables, 0.79 (0.68–0.91) for citrus fruits, and 0.74 (0.66–0.84) for yellow–orange vegetables. Subgroup analysis showed study design and gender as possible sources of heterogeneity. A nonlinear relationship was found of citrus fruits intake with risk of bladder cancer (P for nonlinearity = 0.018), and the RRs (95 % CI) of bladder cancer were 0.87 (0.78–0.96), 0.80 (0.67–0.94), 0.79 (0.66–0.94), 0.79 (0.65–0.96), and 0.79 (0.64–0.99) for 30, 60, 90, 120, and 150 g/day. A nonlinear relationship was also found of yellow–orange vegetable intake with risk of bladder cancer risk (P for nonlinearity = 0.033). Some evidence of publication bias was observed for fruit, citrus fruits, and yellow–orange vegetables.This meta-analysis supports the hypothesis that intakes of fruit and vegetables may reduce the risk of bladder cancer. Future well-designed studies are required to confirm this finding.
Starting Page	1645
Ending Page	1658
Page Count	14
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	25
Issue Number	12
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2014-09-24
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bladder cancer Bladder neoplasms Meta-analysis Fruit Vegetable Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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