NDLI: Energy balance, early life body size, and plasma prolactin levels in postmenopausal women

Content Provider	Springer Nature Link
Author	Su, Xuefen Hankinson, Susan E. Clevenger, Charles V. Eliassen, A. Heather Tworoger, Shelley S.
Copyright Year	2008
Abstract	We examined the relationships of prolactin with birth weight; childhood, adolescent and adult body size measures; adult physical activity and inactivity; and alcohol consumption among 1,423 postmenopausal women from the Nurses’ Health Study.Information on exposures was collected on biennial questionnaires beginning in 1976. Blood was collected from 32,826 participants in 1990; prolactin was measured in a subset of women who were controls for a nested breast cancer case–control study. Generalized linear models were adjusted for assay batch, medication use at blood draw, and other potential predictors of prolactin.No associations were observed for adult factors (p-trend ≥ 0.17), body mass index at age 18, birth weight, or height (p-trend ≥ 0.27). There was an inverse association between body size at ages 5 (p-trend = 0.03) and 10 (p-trend = 0.05) and prolactin, with levels 9% lower among women with the heaviest versus leanest average childhood body size. This association was more pronounced among women with a birth weight <7 pounds (p-trend = 0.004; p-interaction between birth weight and childhood body size = 0.01).Our results suggest that few adult lifestyle risk factors are associated with prolactin levels in postmenopausal women; however, childhood body size may be a predictor of levels later in life.
Starting Page	253
Ending Page	262
Page Count	10
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	20
Issue Number	2
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2008-10-14
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Energy balance Early life body size Prolactin Hematology Epidemiology Public Health/Gesundheitswesen Oncology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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