NDLI: Serum triglycerides and cancer risk in the metabolic syndrome and cancer (Me-Can) collaborative study

Content Provider	Springer Nature Link
Author	Borena, Wegene Stocks, Tanja Jonsson, Håkan Strohmaier, Susanne Nagel, Gabriele Bjørge, Tone Manjer, Jonas Hallmans, Göran Selmer, Randi Almquist, Martin Häggström, Christel Engeland, Anders Tretli, Steinar Concin, Hans Strasak, Alexander Stattin, Pär Ulmer, Han
Copyright Year	2010
Abstract	To assess the association between serum triglyceride levels and cancer risk.The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included data on 257,585 men and 256,512 women. The mean age at study entry was 43.8 years for men and 44.2 years for women. The mean follow-up time was 13.4 years (SD = 8.5) for men and 11.9 years (SD = 7.2) for women. Excluding the first year of follow-up, 23,060 men and 15,686 women were diagnosed with cancer. Cox regression models were used to calculate relative risk (RR) of cancer for triglyceride levels in quintiles and as a continuous variable. RRs were corrected for random error by use of regression dilution ratio.Relative risk for top quintile versus bottom quintile of triglycerides of overall cancer was 1.16 (95% confidence interval 1.06–1.26) in men and 1.15 (1.05–1.27) in women. For specific cancers, significant increases for top quintile versus bottom quintile of triglycerides among men were found for cancers of the colon, respiratory tract, the kidney, melanoma and thyroid and among women, for respiratory, cervical, and non-melanoma skin cancers.Data from our study provided evidence for a possible role of serum triglycerides in cancer development.
Starting Page	291
Ending Page	299
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	22
Issue Number	2
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-12-08
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lipids Prospective study Cancer incidence Hematology Epidemiology Public Health/Gesundheitswesen Oncology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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