NDLI: Alternative approaches to assessing intervention effectiveness in randomized trials: application in a colorectal cancer screening study

Content Provider	Springer Nature Link
Author	Maxwell, Annette E. Crespi, Catherine M. Danao, Leda L. Antonio, Cynthia Garcia, Gabriel M. Bastani, Roshan
Copyright Year	2011
Abstract	Previous analysis of a randomized community-based trial of a multi-component intervention to increase colorectal cancer (CRC) screening among Filipino Americans (n = 548) found significantly higher screening rates in the two intervention groups compared to the control group, when using intent-to-treat analysis and self-reported screening as the outcome. This report describes more nuanced findings obtained from alternative approaches to assessing intervention effectiveness to inform future intervention implementation.The effect of the intervention on CRC screening receipt during follow-up was estimated using methods that adjusted for biases due to missing data and self-report and for different combinations of intervention components. Adjustment for self-report used data from a validation substudy. Effectiveness within demographic subgroups was also examined.Analyses accounting for self-report bias and missing data supported the effectiveness of the intervention. The intervention was also broadly effective across the demographic characteristics of the sample. Estimates of the intervention effect were highest among participants whose providers received a letter as part of the intervention.The findings increase confidence that the intervention could be broadly effective at increasing CRC screening in this population. Subgroup analyses and attempts to deconstruct multi-component interventions can provide important information for future intervention development, implementation, and dissemination.
Starting Page	1233
Ending Page	1241
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	22
Issue Number	9
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-06-16
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Colorectal cancer Cancer screening Immigrants Validation of self-report Subgroup analysis Cancer Research Oncology Hematology Public Health/Gesundheitswesen Epidemiology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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Alternative approaches to assessing intervention effectiveness in randomized trials: Application in a colorectal cancer screening study

The influence of physicians on colorectal cancer screening behavior

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Alternative approaches to assessing intervention effectiveness in randomized trials: application in a colorectal cancer screening study

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Alternative approaches to assessing intervention effectiveness in randomized trials: application in a colorectal cancer screening study