NDLI: Equivalent Current Dipole of Word Repetition Effects in Patients with Obsessive-Compulsive Disorder

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Equivalent Current Dipole of Word Repetition Effects in Patients with Obsessive-Compulsive Disorder

Content Provider	Springer Nature Link
Author	Kim, Young Youn Yoo, So Young Kim, Myung Sun Kwon, Jun Soo
Copyright Year	2006
Abstract	We investigated cortical source localization of word repetition effects in patients with obsessive-compulsive disorder (OCD) by employing the equivalent current dipole (ECD) model with high-density 128 channels EEG and individual MRI as a realistic head model. Twelve OCD patients and 13 healthy control subjects performed a word/nonword discrimination task, in which the words and nonwords were visually presented, and some of the words appeared twice with a lag of one or five items. During the 200–500 ms post-stimulus period, the control group showed more positivity in the ERPs elicited by old words than in those elicited by new words, whereas the OCD patients did not. Furthermore, the OCD patients showed prolonged response times to the old words, as compared to the controls. We calculated the location and the power of the ECD sources at approximately 400 ms post-stimulus with the peak mean global field potentials. In both groups, the sources of word repetition effects were determined to be located in the inferior frontal gyrus. The right ECD powers of the ERP generators elicited by the new words were significantly higher in the OCD patients than in the control subjects. The OCD patients also exhibited significant alterations in the hemispheric asymmetry of ECD power during the processing of new words. These results suggest that OCD patients suffer from the encoding deficits in word processing, particularly in the left hemisphere.
Starting Page	201
Ending Page	212
Page Count	12
File Format	PDF
ISSN	08960267
Journal	Brain Topography
Volume Number	18
Issue Number	3
e-ISSN	15736792
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-03-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	OCD Equivalent current dipole Word repetition effects Inferior frontal gyrus Encoding deficits Neurosciences Neurology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Neurology Anatomy Radiology, Nuclear Medicine and Imaging Neurology (clinical) Radiological and Ultrasound Technology

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