NDLI: Methohexital-Induced Changes in Spectral Power of Neuromagnetic Signals: Beta Augmentation is Smaller Over the Hemisphere Containing the Epileptogenic Focus

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Methohexital-Induced Changes in Spectral Power of Neuromagnetic Signals: Beta Augmentation is Smaller Over the Hemisphere Containing the Epileptogenic Focus

8th World Congress of the International Society for Brain Electromagnetic Topography (ISBET) with The KEY Foundation Symposium “Brain Fields in Psychiatry”

6th German EEG/EP Mapping Meeting

Brain Topography : Volume 9

Methohexital-Induced Changes in Spectral Power of Neuromagnetic Signals: Beta Augmentation is Smaller Over the Hemisphere Containing the Epileptogenic Focus

Content Provider	Springer Nature Link
Author	Wienbruch, Christian Eulitz, Carsten Lehnertz, Klaus Brockhaus, Anke Elger, Christian E. Elbert, Thomas Hoke, Manfried
Copyright Year	1997
Abstract	Previous research has suggested that methohexital, a short-term barbiturate, alters activity in the primary epileptogenic area. It can be assumed that drug-induced activation of the epileptogenic focus provides a rapid and safe method to obtain a sufficient amount of information relevant for the lateralization and localisation of the primary epileptogenic area. This study shows that methohexital changes spectral power in the beta band derived from magnetoencephalographic (MEG) signals over the hemisphere ipsilateral to the primary epileptogenic area. This effect was demonstrated for 10/13 of the investigated patients suffering from unilateral temporal lobe epilepsy (TLE). The side and location of the primary epileptogenic area of these patients (5 left TLE, 8 right TLE) was determined invasively during presurgical evaluation. During a 1-2 minute interval after intravenous bolus injection of 100 mg methohexital a clear lateralization effect in the beta band was observed, which differed marginally between fronto-central, fronto-temporal and temporo-parietal brain regions. In addition, bilateral spectral power changes were obtained in the theta, alpha and gamma bands that differed between brain regions. Analyses of simultaneously recorded scalp electroencephalographic (EEG) data revealed effects consistent with those of the MEG analysis. The reduced enhancement of beta band spectral power of MEG recordings provides a potential application for the non-invasive lateralization of the primary epileptogenic area.
Starting Page	41
Ending Page	47
Page Count	7
File Format	PDF
ISSN	08960267
Journal	Brain Topography
Volume Number	10
Issue Number	1
e-ISSN	15736792
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1997-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Neurology Anatomy Radiology, Nuclear Medicine and Imaging Neurology (clinical) Radiological and Ultrasound Technology

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