NDLI: Relationship Between Flow and Metabolism in BOLD Signals: Insights from Biophysical Models

Content Provider	Springer Nature Link
Author	Blanchard, Solenna Papadopoulo, Théo Bénar, Christian George Voges, Nicole Clerc, Maureen Benali, Habib Warnking, Jan David, Olivier Wendling, Fabrice
Copyright Year	2010
Abstract	In many physiological or pathological situations, the interpretation of BOLD signals remains elusive as the intimate link between neuronal activity and subsequent flow/metabolic changes is not fully understood. During the past decades, a number of biophysical models of the neurovascular coupling have been proposed. It is now well-admitted that these models may bridge between observations (fMRI data) and underlying biophysical and (patho-)physiological mechanisms (related to flow and metabolism) by providing mechanistic explanations. In this study, three well-established models (Buxton’s, Friston’s and Sotero’s) are investigated. An exhaustive parameter sensitivity analysis (PSA) was conducted to study the marginal and joint influences of model parameters on the three main features of the BOLD response (namely the principal peak, the post-stimulus undershoot and the initial dip). In each model, parameters that have the greatest (and least) influence on the BOLD features as well as on the direction of variation of these features were identified. Among the three studied models, parameters were shown to affect the output features in different manners. Indeed, the main parameters revealed by the PSA were found to strongly depend on the way the flow(CBF)-metabolism(CMRO2) relationship is implemented (serial vs. parallel). This study confirmed that the model structure which accounts for the representation of the CBF–CMRO2 relationship (oxygen supply by the flow vs. oxygen demand from neurons) plays a key role. More generally, this work provides substantial information about the tuning of parameters in the three considered models and about the subsequent interpretation of BOLD signals based on these models.
Starting Page	40
Ending Page	53
Page Count	14
File Format	PDF
ISSN	08960267
Journal	Brain Topography
Volume Number	24
Issue Number	1
e-ISSN	15736792
Language	English
Publisher	Springer US
Publisher Date	2010-11-06
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	BOLD signal Biophysical models CBF–CMRO2 relationship Parameter sensitivity analysis Neurology Psychiatry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neurology Anatomy Radiology, Nuclear Medicine and Imaging Neurology (clinical) Radiological and Ultrasound Technology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Assessing the Spatial Precision of SE and GE-BOLD Contrast at 7 Tesla

Point-Process Deconvolution of fMRI BOLD Signal Reveals Effective Connectivity Alterations in Chronic Pain Patients

Spatial Nonuniformity of the Resting CBF and BOLD Responses to Sevoflurane: In Vivo Study of Normal Human Subjects With Magnetic Resonance Imaging

Lambda Waves: Incidence and Relationship to Photic Driving

Connecting Mean Field Models of Neural Activity to EEG and fMRI Data

Discussing Gamma

Negative BOLD Response to Interictal Epileptic Discharges in Focal Epilepsy

Signal Space Separation Beamformer

Modeling of the Neurovascular Coupling in Epileptic Discharges

Relationship Between Flow and Metabolism in BOLD Signals: Insights from Biophysical Models

Similar Documents

Assessing the Spatial Precision of SE and GE-BOLD Contrast at 7 Tesla

Point-Process Deconvolution of fMRI BOLD Signal Reveals Effective Connectivity Alterations in Chronic Pain Patients

Spatial Nonuniformity of the Resting CBF and BOLD Responses to Sevoflurane: In Vivo Study of Normal Human Subjects With Magnetic Resonance Imaging

Lambda Waves: Incidence and Relationship to Photic Driving

Connecting Mean Field Models of Neural Activity to EEG and fMRI Data

Discussing Gamma

Negative BOLD Response to Interictal Epileptic Discharges in Focal Epilepsy

Signal Space Separation Beamformer

Modeling of the Neurovascular Coupling in Epileptic Discharges

Relationship Between Flow and Metabolism in BOLD Signals: Insights from Biophysical Models