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| Content Provider | Springer Nature Link |
|---|---|
| Author | Xu, Xiaxia Zheng, Chenguang An, Lei Wang, Rubin Zhang, Tao |
| Copyright Year | 2016 |
| Abstract | Theta and gamma oscillations are believed to play an important role in cognition and memory, and their phase coupling facilitates the information transmission in hippocampal-cortex network. In a rat model of chronic stress, the phase coupling of both theta and gamma oscillations between ventral hippocampal CA1 (vCA1) and medial prefrontal cortex (mPFC) was found to be disrupted, which was associated with the impaired synaptic plasticity in the pathway. However, little was known about the mechanisms underlying the process. In order to address this issue, both dopamine and serotonin as monoaminergic neurotransmitters were involved in this study, since they were crucial factors in pathological basis of depressive disorder. Local field potentials (LFPs) were recorded simultaneously at both vCA1 and mPFC regions under anesthesia, before and after the injection of dopamine D1 receptor antagonist and 5-HT1A receptor agonist, respectively. The results showed that the blockage of D1 receptor could lead to depression-like decrement on theta phase coupling. In addition, the activation of 5-HT1A receptor enhanced vCA1–mPFC coupling on gamma oscillations, and attenuated CA1 theta-fast gamma cross frequency coupling. These data suggest that the theta phase coupling between vCA1 and mPFC may be modulated by dopamine system that is an underlying mechanism of the cognitive dysfunction in depression. Besides, the serotonergic system is probably involved in the regulation of gamma oscillations coupling in vCA1–mPFC network. |
| Starting Page | 539 |
| Ending Page | 551 |
| Page Count | 13 |
| File Format | |
| ISSN | 08960267 |
| Journal | Brain Topography |
| Volume Number | 29 |
| Issue Number | 4 |
| e-ISSN | 15736792 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2016-03-11 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Ventral hippocampus Prefrontal cortex Theta rhythm Gamma oscillations Dopamine 5-HT Neurosciences Psychiatry Neurology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Anatomy Radiology, Nuclear Medicine and Imaging Neurology (clinical) Radiological and Ultrasound Technology |
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