NDLI: Multiphysics simulation of a microfluidic perfusion chamber for brain slice physiology

Content Provider	Springer Nature Link
Author	Caicedo, Hector H. Hernandez, Maximilia Fall, Christopher P. Eddington, David T.
Copyright Year	2010
Abstract	Understanding and optimizing fluid flows through in vitro microfluidic perfusion systems is essential in mimicking in vivo conditions for biological research. In a previous study a microfluidic brain slice device (μBSD) was developed for microscale electrophysiology investigations. The device consisted of a standard perfusion chamber bonded to a polydimethylsiloxane (PDMS) microchannel substrate. Our objective in this study is to characterize the flows through the μBSD by using multiphysics simulations of injections into a pourous matrix to identify optimal spacing of ports. Three-dimensional computational fluid dynamic (CFD) simulations are performed with CFD-ACE + software to model, simulate, and assess the transport of soluble factors through the perfusion bath, the microchannels, and a material that mimics the porosity, permeability and tortuosity of brain tissue. Additionally, experimental soluble factor transport through a brain slice is predicted by and compared to simulated fluid flow in a volume that represents a porous matrix material. The computational results are validated with fluorescent dye experiments.
Starting Page	761
Ending Page	767
Page Count	7
File Format	PDF
ISSN	13872176
Journal	Biomedical Microdevices
Volume Number	12
Issue Number	5
e-ISSN	15728781
Language	English
Publisher	Springer US
Publisher Date	2010-05-13
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microfluidics Computational fluid dynamics (CFD) simulations Organotypic brain slice cultures (OBSC) Engineering Fluid Dynamics Nanotechnology Biophysics and Biological Physics Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Molecular Biology Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Multiphysics simulation of a microfluidic perfusion chamber for brain slice physiology

Perfused drop microfluidic device for brain slice culture-based drug discovery

Three dimensional MEMS microfluidic perfusion system for thick brain slice cultures

“Artificial micro organs”—a microfluidic device for dielectrophoretic assembly of liver sinusoids

Numerical and experimental characterization of a novel modular passive micromixer

Practical fabrication of microfluidic platforms for live-cell microscopy

Microfluidic array for three-dimensional perfusion culture of human mammary epithelial cells

Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber

A self-contained microfluidic cell culture system

Multiphysics simulation of a microfluidic perfusion chamber for brain slice physiology

Similar Documents

Multiphysics simulation of a microfluidic perfusion chamber for brain slice physiology

Perfused drop microfluidic device for brain slice culture-based drug discovery

Three dimensional MEMS microfluidic perfusion system for thick brain slice cultures

“Artificial micro organs”—a microfluidic device for dielectrophoretic assembly of liver sinusoids

Numerical and experimental characterization of a novel modular passive micromixer

Practical fabrication of microfluidic platforms for live-cell microscopy

Microfluidic array for three-dimensional perfusion culture of human mammary epithelial cells

Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber

A self-contained microfluidic cell culture system

Multiphysics simulation of a microfluidic perfusion chamber for brain slice physiology