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| Content Provider | Springer Nature Link |
|---|---|
| Author | Yang, Chang Yang, Yanli Gupta, Nishith Liu, Xiaojun He, Aibin Liu, Lizhong Zuo, Jin Chang, Yongsheng Fang, Fude |
| Copyright Year | 2007 |
| Abstract | This study constitutes the first report revealing the participation of prominin-1 in glucose metabolism and cytoskeleton alteration. Upon stimulation with high glucose, the expression of prominin-1 was up-regulated with concomitant down-regulation of its phosphorylation. Prominin-1 mutated at its phosphorylation site inflicted a global change in the expression of several genes associated with glucose metabolism in L6 myotube cells. Further, the over-expression of prominin-1 promoted glucose uptake in these cells. Prominin-1 undergoes sustained repression of its expression during confluence and differentiation of L6 myotube cells. The expression of prominin-1 in the MDCK cell modulated cell morphology and promoted cellular migration. These data imply that prominin-1 is involved in glucose metabolism and may regulate cellular glucose through its effect on cytoskeleton. |
| Starting Page | 854 |
| Ending Page | 862 |
| Page Count | 9 |
| File Format | |
| ISSN | 00062979 |
| Journal | Biochemistry (Moscow) |
| Volume Number | 72 |
| Issue Number | 8 |
| e-ISSN | 16083040 |
| Language | English |
| Publisher | Nauka/Interperiodica |
| Publisher Date | 2007-01-01 |
| Publisher Place | Moscow |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | prominin-1 CD133/AC133 glucose cytoskeleton Biochemistry Bioorganic Chemistry Microbiology Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Biophysics Geriatrics and Gerontology |
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