NDLI: Downregulation of genes encoding for subunits of adaptor complex-3 in cervical carcinomas

Content Provider	Springer Nature Link
Author	Petrenko, A. A. Pavlova, L. S. Karseladze, A. I. Kisseljov, F. L. Kisseljova, N. P.
Copyright Year	2006
Abstract	We explored the expression of four genes encoding for subunits of AP-3 in cervical tumors and cancer cell lines. Using RT-PCR we demonstrated more than twofold decrease in the levels of mRNA of AP3D1, AP3B1, AP3M1, and AP3S1 in 32, 28, 23, and 26% tumors in comparison with normal tissues of uterine cervix, respectively. The level of mRNA of at least one subunit was decreased in 28 out of 47 (60%) of tumors and in four out of five cancer cell lines in comparison to tissues adjacent to tumors. The suppression of expression of any of the subunits was revealed in 15 out of 28 cases (54%). The expression of two and more subunits was decreased simultaneously in different combinations in 13 cases (46%). This fact testifies to the lack of a common mechanism of downregulation of four subunits in tumors. There is a tendency to more frequent suppression of AP-3A expression in tumors associated with lymphatic node metastases as compared with tumors without metastases (P = 0.034). Thus, here we demonstrate for the first time the decrease in expression of genes encoding for AP-3A subunits in tumors.
Starting Page	1153
Ending Page	1160
Page Count	8
File Format	PDF
ISSN	00062979
Journal	Biochemistry (Moscow)
Volume Number	71
Issue Number	10
e-ISSN	16083040
Language	English
Publisher	Nauka/Interperiodica
Publisher Date	2006-01-01
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	gene AP3D1 gene AP3B1 gene AP3M1 gene AP3S1 intracellular transport of proteins uterine cervix cancer metastases Biomedicine general Bioorganic Chemistry Biochemistry Microbiology
Content Type	Text
Resource Type	Article
Subject	Biochemistry Biophysics Geriatrics and Gerontology

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