NDLI: Possible mechanisms of acquisition of herpesvirus virokines

Content Provider	Springer Nature Link
Author	Gorshkova, E. A. Shilov, E. S.
Copyright Year	2016
Abstract	The genomes of certain types of human and primate herpesviruses contain functional homologs of important host cytokines (IL-6, IL-17, and IL-10), or so-called virokines. Virokines can interact with immune cell receptors, transmit a signal to them, and thus switch the type of immune response that facilitates viral infection development. In this work, we have summarized possible ways of virokine origin and proposed an evolutionary scenario of virokine acquisition with involvement of retroviral coinfection of the host. This scenario is probably valid for vIL-6 of HHV-8 and MRV-5 viruses, vIL-17 of HVS virus, and vIL-10 of HHV-4, Bonobo-HV, RhLCV, and BaLCV viruses. The ability to acquire cytokine genes allows herpesviruses to implement unique strategies of avoiding the immune response and provides them an evolutionary advantage: more than 90% of the host population can be chronically infected with different herpesviruses. It is possible that the biological success of herpesviruses can be partially due to their cooperation with another group of viruses. This hypothesis emphasizes the importance of studies on the reciprocal influence of pathogens on their coinfection, as well as their impact on the host organism.
Starting Page	1350
Ending Page	1357
Page Count	8
File Format	PDF
ISSN	00062979
Journal	Biochemistry (Moscow)
Volume Number	81
Issue Number	11
e-ISSN	16083040
Language	English
Publisher	Pleiades Publishing
Publisher Date	2016-11-13
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	virokines IL-6 IL-10 IL-17 herpesviruses retroviruses horizontal gene transfer Biochemistry Bioorganic Chemistry Microbiology Biomedicine
Content Type	Text
Resource Type	Article
Subject	Biochemistry Biophysics Geriatrics and Gerontology

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