NDLI: Types of immune-inflammatory responses as a reflection of cell–cell interactions under conditions of tissue regeneration and tumor growth

Content Provider	Springer Nature Link
Author	Tashireva, L. A. Perelmuter, V. M. Manskikh, V. N. Denisov, E. V. Savelieva, O. E. Kaygorodova, E. V. Zavyalova, M. V.
Copyright Year	2017
Abstract	Inflammatory infiltration of tumor stroma is an integral reflection of reactions that develop in response to any damage to tumor cells including immune responses to antigens or necrosis caused by vascular disorders. In this review, we use the term “immune-inflammatory response” (IIR) that allows us to give an integral assessment of the cellular composition of the tumor microenvironment. Two main types of IIRs are discussed: type 1 and 2 T-helper reactions (Th1 and Th2), as well as their inducers: immunosuppressive responses and reactions mediated by Th22 and Th17 lymphocytes and capable of modifying the main types of IIRs. Cellular and molecular manifestations of each IIR type are analyzed and their general characteristics and roles in tissue regeneration and tumor growth are presented. Since inflammatory responses in a tumor can also be initiated by innate immunity mechanisms, special attention is given to inflammation based on them. We emphasize that processes accompanying tissue regeneration are prototypes of processes underlying cancer progression, and these processes have the same cellular and molecular substrates. We focus on evidence that tumor progression is mainly contributed by processes specific for the second phase of “wound healing” that are based on the Th2-type IIR. We emphasize that the effect of various types of immune and stroma cells on tumor progression is determined by the ability of the cells and their cytokines to promote or prevent the development of Th1- or Th2-type of IIR. Finally, we supposed that the nonspecific influence on the tumor caused by the cytokine context of the Th1- or Th2-type microenvironment should play a decisive role for suppression or stimulation of tumor growth and metastasis.
Starting Page	542
Ending Page	555
Page Count	14
File Format	PDF
ISSN	00062979
Journal	Biochemistry (Moscow)
Volume Number	82
Issue Number	5
e-ISSN	16083040
Language	English
Publisher	Pleiades Publishing
Publisher Date	2017-05-19
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	immune-inflammatory response lymphocyte subpopulations macrophages fibroblasts tissue regeneration tumor progression Biochemistry Bioorganic Chemistry Microbiology Biomedicine
Content Type	Text
Resource Type	Article
Subject	Biochemistry Biophysics Geriatrics and Gerontology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Tissue-specific transcription factors in progression of epithelial tumors

Biochemical aspects of inflammation

Secretion of adipocytes and macrophages under conditions of inflammation and/or insulin resistance and effect of adipocytes on preadipocytes under these conditions

Intratumor heterogeneity: Nature and biological significance

Mechanisms of changes in immune response during bacterial coinfections of the respiratory tract

Cell–cell interactions in bacterial populations

Cell—cell interactions in bacterial populations

Epitope mapping of lymphocyte phosphatase-associated phosphoprotein

Do mitochondria have an immune system?

Types of immune-inflammatory responses as a reflection of cell–cell interactions under conditions of tissue regeneration and tumor growth

Similar Documents

Tissue-specific transcription factors in progression of epithelial tumors

Biochemical aspects of inflammation

Secretion of adipocytes and macrophages under conditions of inflammation and/or insulin resistance and effect of adipocytes on preadipocytes under these conditions

Intratumor heterogeneity: Nature and biological significance

Mechanisms of changes in immune response during bacterial coinfections of the respiratory tract

Cell–cell interactions in bacterial populations

Cell—cell interactions in bacterial populations

Epitope mapping of lymphocyte phosphatase-associated phosphoprotein

Do mitochondria have an immune system?

Types of immune-inflammatory responses as a reflection of cell–cell interactions under conditions of tissue regeneration and tumor growth