NDLI: Lactoferrin for prevention of neonatal sepsis

Content Provider	Springer Nature Link
Author	Turin, Christie G. Zea Vera, Alonso Pezo, Alonso Cruz, Karen Zegarra, Jaime Bellomo, Sicilia Cam, Luis Llas, Raul Castañeda, Anne Tucto, Lourdes Ochoa, Theresa J.
Copyright Year	2014
Abstract	Preterm neonates are at risk to acquire infections. In addition to the high mortality associated with sepsis, these patients are at risk for long-term disabilities, particularly neurodevelopment impairment. Several interventions have been evaluated to reduce rates of infections in neonates but have not proven efficacy. Lactoferrin (LF), a milk glycoprotein with anti-inflammatory, immunomodulatory and anti-microbial properties, has the potential to prevent infections in young children. We performed a review of current and ongoing clinical trials of LF for prevention of neonatal sepsis, and found eleven registered clinical trials that include more than 6,000 subjects. Few of these trials have finished; despite their small sample size, the preliminary results show a trend towards a positive protective effect of LF on neonatal infections. Larger trials are underway to confirm the findings of these initial studies. This information will help to define LF’s role in clinical settings and, if proven effective, would profoundly affect the treatment of low birth weight neonates as a cost-effective intervention worldwide.
Starting Page	1007
Ending Page	1016
Page Count	10
File Format	PDF
ISSN	09660844
Journal	BioMetals
Volume Number	27
Issue Number	5
e-ISSN	15728773
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-06-17
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lactoferrin Bovine lactoferrin Recombinant human lactoferrin Neonatal sepsis Prevention Clinical trial Biochemistry Pharmacology/Toxicology Microbiology Cell Biology Plant Physiology Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Metals and Alloys Biochemistry, Genetics and Molecular Biology Biomaterials Agricultural and Biological Sciences

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Expression and characterization of recombinant bovine lactoferrin in E. coli

Erratum to: Expression and characterization of recombinant bovine lactoferrin in E. coli

Transcriptomic profiling of intestinal epithelial cells in response to human, bovine and commercial bovine lactoferrins

Inhibition of intestinal polyp growth by oral ingestion of bovine lactoferrin and immune cells in the large intestine

Lactoferrin and bifidobacteria

Prebiotic effects of bovine lactoferrin on specific probiotic bacteria

Effect of bovine apo-lactoferrin on the growth and virulence of Actinobacillus pleuropneumoniae

Behavioral effects of bovine lactoferrin administration during postnatal development of rats

The lactoferrin receptor may mediate the reduction of eosinophils in the duodenum of pigs consuming milk containing recombinant human lactoferrin

Lactoferrin for prevention of neonatal sepsis

Similar Documents

Expression and characterization of recombinant bovine lactoferrin in E. coli

Erratum to: Expression and characterization of recombinant bovine lactoferrin in E. coli

Transcriptomic profiling of intestinal epithelial cells in response to human, bovine and commercial bovine lactoferrins

Inhibition of intestinal polyp growth by oral ingestion of bovine lactoferrin and immune cells in the large intestine

Lactoferrin and bifidobacteria

Prebiotic effects of bovine lactoferrin on specific probiotic bacteria

Effect of bovine apo-lactoferrin on the growth and virulence of Actinobacillus pleuropneumoniae

Behavioral effects of bovine lactoferrin administration during postnatal development of rats

The lactoferrin receptor may mediate the reduction of eosinophils in the duodenum of pigs consuming milk containing recombinant human lactoferrin

Lactoferrin for prevention of neonatal sepsis