NDLI: Treatment strategies in Alzheimer’s disease: a review with focus on selenium supplementation

Content Provider	Springer Nature Link
Author	Aaseth, Jan Alexander, Jan Bjørklund, Geir Hestad, Knut Dusek, Petr Roos, Per M. Alehagen, Urban
Copyright Year	2016
Abstract	Alzheimer’s disease (AD) is a neurodegenerative disorder presenting one of the biggest healthcare challenges in developed countries. No effective treatment exists. In recent years the main focus of AD research has been on the amyloid hypothesis, which postulates that extracellular precipitates of beta amyloid (Aβ) derived from amyloid precursor protein (APP) are responsible for the cognitive impairment seen in AD. Treatment strategies have been to reduce Aβ production through inhibition of enzymes responsible for its formation, or to promote resolution of existing cerebral Aβ plaques. However, these approaches have failed to demonstrate significant cognitive improvements. Intracellular rather than extracellular events may be fundamental in AD pathogenesis. Selenate is a potent inhibitor of tau hyperphosphorylation, a critical step in the formation of neurofibrillary tangles. Some selenium (Se) compounds e.g. selenoprotein P also appear to protect APP against excessive copper and iron deposition. Selenoproteins show anti-inflammatory properties, and protect microtubules in the neuronal cytoskeleton. Optimal function of these selenoenzymes requires higher Se intake than what is common in Europe and also higher intake than traditionally recommended. Supplementary treatment with N-acetylcysteine increases levels of the antioxidative cofactor glutathione and can mediate adjuvant protection. The present review discusses the role of Se in AD treatment and suggests strategies for AD prevention by optimizing selenium intake, in accordance with the metal dysregulation hypothesis. This includes in particular secondary prevention by selenium supplementation to elderly with mild cognitive impairment.
Starting Page	827
Ending Page	839
Page Count	13
File Format	PDF
ISSN	09660844
Journal	BioMetals
Volume Number	29
Issue Number	5
e-ISSN	15728773
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-08-16
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Alzheimer’s disease Copper Iron Neuroinflammation Transmitters Selenium Biochemistry Pharmacology/Toxicology Microbiology Cell Biology Plant Physiology Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Metals and Alloys Biochemistry, Genetics and Molecular Biology Biomaterials Agricultural and Biological Sciences

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Treatment strategies in Alzheimer’s disease: a review with focus on selenium supplementation

The many “faces” of copper in medicine and treatment

Transition metal abnormalities in progressive dementias

Does any drug to treat cancer target mTOR and iron hemostasis in neurodegenerative disorders?

Predictive association of copper metabolism proteins with Alzheimer’s disease and Parkinson’s disease: a preliminary perspective

Selenium as an antidote in the treatment of mercury intoxication

Ferrous iron content of intravenous iron formulations

An overview of various mammalian models to study chronic copper intoxication associated Alzheimer’s disease like pathology

The neurotoxicity of iron, copper and cobalt in Parkinson’s disease through ROS-mediated mechanisms

Treatment strategies in Alzheimer’s disease: a review with focus on selenium supplementation

Similar Documents

Treatment strategies in Alzheimer’s disease: a review with focus on selenium supplementation

The many “faces” of copper in medicine and treatment

Transition metal abnormalities in progressive dementias

Does any drug to treat cancer target mTOR and iron hemostasis in neurodegenerative disorders?

Predictive association of copper metabolism proteins with Alzheimer’s disease and Parkinson’s disease: a preliminary perspective

Selenium as an antidote in the treatment of mercury intoxication

Ferrous iron content of intravenous iron formulations

An overview of various mammalian models to study chronic copper intoxication associated Alzheimer’s disease like pathology

The neurotoxicity of iron, copper and cobalt in Parkinson’s disease through ROS-mediated mechanisms

Treatment strategies in Alzheimer’s disease: a review with focus on selenium supplementation