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| Content Provider | Springer Nature Link |
|---|---|
| Author | Long, Xiao Hui Yang, Peng Yuan Liu, Qiong Yao, Jun Wang, Yi He, Guo Hua Hong, Guang Yan Ni, Jia Zuan |
| Copyright Year | 2011 |
| Abstract | Lanthanides (Lns) compounds have been reported to possess contrary effects on cell activity, i.e., promoting cell cycle progression and cell growth by lower concentration treatment, but suppressing cell proliferation and inducing cell apoptosis at higher dosing. However, the cellular processes during the intervention and the possible underlying mechanisms are still not well clarified. Using a combination of high-throughput liquid chromatography (LC) with mass spectrometry (MS), we have investigated the metabolomic profiles of Hela cells following gadolinium chloride (GdCl3) treatment in time- and concentration- dependent manners. A total of 48 metabolites released by Hela cells are identified to be differentially expressed (P < 0.05) in different states. Metabolic pathways analyses reveal that the differential metabolites are mainly characterized by increased lipid and amino acid metabolisms and by decreased lipid, amino acid, and carbohydrate metabolisms for cells treated with GdCl3 at lower and higher concentrations, respectively. Notably, in the higher level GdCl3 case, the down-expressions of metabolites are predominantly in the glycolytic and the redox pathways. The above results, obtained by using a metabolomic strategy for the first time, disclose that different cell signaling pathways are activated by GdCl3 treatment with different concentrations, leading to inhibitory or promotional effect on Hela cells. |
| Starting Page | 663 |
| Ending Page | 677 |
| Page Count | 15 |
| File Format | |
| ISSN | 09660844 |
| Journal | BioMetals |
| Volume Number | 24 |
| Issue Number | 4 |
| e-ISSN | 15728773 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2011-02-04 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Gadolinium chloride Hela cells Metabolomic profiling Liquid chromatography-mass spectrometry Cell growth Physical Chemistry Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Metals and Alloys Biochemistry, Genetics and Molecular Biology Biomaterials Agricultural and Biological Sciences |
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