NDLI: Expression of delta-lactoferrin induces cell cycle arrest

Content Provider	Springer Nature Link
Author	Breton, Mathilde Mariller, Christophe Benaïssa, Monique Caillaux, Katia Browaeys, Edith Masson, Maryse Vilain, Jean Pierre Mazurier, Joël Pierce, Annick
Copyright Year	2004
Abstract	Delta-lactoferrin (ΔLf) mRNA is the product of alternative splicing of the Lf gene. It has been found in normal tissues and was reported to be absent from their malignant counterparts. Our recent investigations have shown that ΔLf expression is a good prognostic indicator in human breast cancer. However, ΔLf has up till now only been identified as a transcript, and in order to characterize the ΔLf protein and determine its function we have used a ΔLf cDNA construct to produce the protein in vitro and in vivo.A 73 kDa protein was immunoprecipitated from in vitro translation products and this molecular weight is in accordance with the use of the first in frame AUG start codon located in exon 2. We also produced a cell line expressing ΔLf under doxycycline induction. Using this model we have been able to show that ΔLf is mainly distributed in the cytoplasm. Its expression induces cell cycle arrest and inhibits cell proliferation. Our results suggest that ΔLf may play an important role in the regulation of normal cell growth.
Starting Page	325
Ending Page	329
Page Count	5
File Format	PDF
ISSN	09660844
Journal	BioMetals
Volume Number	17
Issue Number	3
e-ISSN	15728773
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2004-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Physical Chemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Metals and Alloys Biochemistry, Genetics and Molecular Biology Biomaterials Agricultural and Biological Sciences

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