NDLI: Intra-tumoral injection of CpG results in the inhibition of tumor growth in murine Colon-26 and B-16 tumors

Content Provider	Springer Nature Link
Author	Sharma, Sanjay Karakousis, Constantine P. Takita, Hiroshi Shin, Kyu Brooks, Stephen P.
Copyright Year	2003
Abstract	Direct tumor injections of CpG (ODN #1826) into murine tumors markedly suppressed the tumor growth and increased the survival of the mice. Tumor growth was reduced by 60–67% in Colon Tumor 26 (CT-26) and B-16 melanoma tumors treated with CpG as compared to untreated one. In CT-26 and B-16 tumors treated with CpG, the average survival of the animals were prolonged to 26 and 28 d as compared to 16 and 18 d in control respectively. Long-term surviving animals in CT-26 tumor groups were also protected from a subsequent injection of a lethal dose of tumor cells. In the present study, effect of CpG was mediated through CD8+ T cells, as their depletion resulted in the abrogation of the therapeutic effects of the CpG. It suggests that direct tumor injection might be a simple means of achieving a clinical response in cancer patients.
Starting Page	149
Ending Page	153
Page Count	5
File Format	PDF
ISSN	01415492
Journal	Biotechnology Letters
Volume Number	25
Issue Number	2
e-ISSN	15736776
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2003-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biotechnology Organic Chemistry Biochemistry Microbiology Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Medicine Bioengineering Applied Microbiology and Biotechnology Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Inhibition of microalgal growth by silver nitrate

Inhibition of malolactic fermentation by cryotolerant yeasts

Esterase activity assay by flow injection analysis (FIA)

Efficient gene transfer into murine embryonic stem cells by nucleofection

Inhibition of cellulase activity by sun_ower polyphenols

In vitro growth inhibition of human intestinal bacteria by sarcotoxin IA, an insect bactericidal peptide

Methanol determination in Pichia pastoris cultures by flow injection analysis

Review: Minibioreactors

Thiocyanate degradation by Acremonium strictum and inhibition by secondary toxicants

Intra-tumoral injection of CpG results in the inhibition of tumor growth in murine Colon-26 and B-16 tumors

Similar Documents

Inhibition of microalgal growth by silver nitrate

Inhibition of malolactic fermentation by cryotolerant yeasts

Esterase activity assay by flow injection analysis (FIA)

Efficient gene transfer into murine embryonic stem cells by nucleofection

Inhibition of cellulase activity by sun_ower polyphenols

In vitro growth inhibition of human intestinal bacteria by sarcotoxin IA, an insect bactericidal peptide

Methanol determination in Pichia pastoris cultures by flow injection analysis

Review: Minibioreactors

Thiocyanate degradation by Acremonium strictum and inhibition by secondary toxicants

Intra-tumoral injection of CpG results in the inhibition of tumor growth in murine Colon-26 and B-16 tumors