NDLI: Association Between the G20210A Polymorphism of Prothrombin Gene and Myocardial Infarction in Tunisian Population

Content Provider	Springer Nature Link
Author	Kallel, Amani Sbaï, Mohamed Hedi Sédiri, Yousra Feki, Moncef Mourali, Mohamed Sami Mechmeche, Rachid Jemaa, Riadh Kaabachi, Naziha
Copyright Year	2016
Abstract	The prothrombin is the precursor of the serine protease thrombin, a key enzyme in homeostasis. Prothrombin G20210A polymorphism (rs1799963) was described as a moderate risk factor for venous thrombosis because this mutation is associated with prothrombin elevated levels which may lead to an imbalance between the procoagulant, anticoagulant, and fibrinolytic system. 20210A carriers have an increased risk of thrombosis. In this study, we proposed to determine the prevalence of 20210A prothrombin variant among Tunisian population, and to evaluate the potential relevance of this variant with myocardial infarction. This study included 1290 unrelated Tunisians (1007 male and 283 female) divided in two groups: Four hundred and eighty-seven MI patients (mean age: 52.64 ± 8.98 years) and 803 apparently healthy controls (mean age: 51 ± 8.99). The prothrombin G20210A polymorphism was carried out by polymerase chain reaction/restriction fragment length polymorphism (PCR–RFLP) analysis. The distribution of genotypes was in accordance with Hardy–Weinberg equilibrium (p > 0.05). A significant difference in genotype distribution and allele frequency was observed between patients and controls. Male patients with MI had a frequency of 97 % for GG genotype and 3 % for GA+AA genotypes. The control group had a frequency of 99 % for the GG genotype and 1 % for the GA+AA genotypes which is significantly lower than the frequency found in patients (p = 0.01). The same genotype frequencies were found in women (p = 0.032). The MI patient group showed a significantly higher frequency of 20210A allele compared to controls 0.02 versus 0.01 [OR = 3.60 (95 % CI = 1.29–10.53), p = 0.005] in men and 0.015 versus 0.068 [OR = 4.68 (95 % CI = 1.60–14.26), p = 0.001] in women. Our work showed a significant but not independent association between the G20210A polymorphism of the prothrombin gene and MI in the Tunisian population.
Starting Page	653
Ending Page	664
Page Count	12
File Format	PDF
ISSN	00062928
Journal	Biochemical Genetics
Volume Number	54
Issue Number	5
e-ISSN	15734927
Language	English
Publisher	Springer US
Publisher Date	2016-06-15
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Prothrombin Myocardial infarction Polymorphism Human Genetics Biochemistry Zoology Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Association Between the G20210A Polymorphism of Prothrombin Gene and Myocardial Infarction in Tunisian Population.

Association Between Apolipoprotein E Gene Polymorphism and Myocardial Infarction

Kell Blood Group System Polymorphism in an Urban Tunisian Population

Association of Lymphotoxin Alpha Polymorphism with Type 1 Diabetes in a Tunisian Population

The Relationship between Gene Polymorphism and CRP Level in a Chinese Han Population

Lipoprotein Lipase (A1127G) Gene Polymorphism: A Case–Control Association Study

Association Between IL-10 Gene Promoter Polymorphism and Hepatitis B Viral Infection in an Egyptian Population

Association of AHSG Gene Polymorphisms with Ischemic Stroke in a Han Chinese Population

Association of IL-1 Receptor Antagonist Gene VNTR Polymorphism with Ischemic Stroke in the Chinese Uyghur Population

Association Between the G20210A Polymorphism of Prothrombin Gene and Myocardial Infarction in Tunisian Population

Similar Documents

Association Between the G20210A Polymorphism of Prothrombin Gene and Myocardial Infarction in Tunisian Population.

Association Between Apolipoprotein E Gene Polymorphism and Myocardial Infarction

Kell Blood Group System Polymorphism in an Urban Tunisian Population

Association of Lymphotoxin Alpha Polymorphism with Type 1 Diabetes in a Tunisian Population

The Relationship between Gene Polymorphism and CRP Level in a Chinese Han Population

Lipoprotein Lipase (A1127G) Gene Polymorphism: A Case–Control Association Study

Association Between IL-10 Gene Promoter Polymorphism and Hepatitis B Viral Infection in an Egyptian Population

Association of AHSG Gene Polymorphisms with Ischemic Stroke in a Han Chinese Population

Association of IL-1 Receptor Antagonist Gene VNTR Polymorphism with Ischemic Stroke in the Chinese Uyghur Population

Association Between the G20210A Polymorphism of Prothrombin Gene and Myocardial Infarction in Tunisian Population