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| Content Provider | Springer Nature Link |
|---|---|
| Author | Sri Manjari, K. Nallari, Pratibha Balakrishna, N. Vidyasagar, A. Prabhakar, B. Jyothy, A. Venkateshwari, A. |
| Copyright Year | 2013 |
| Abstract | This study investigated the role of −1607 (1G/2G) (rs1799750) polymorphism of the MMP-1 gene in chronic pancreatitis. We genotyped 100 patients with chronic pancreatitis and 100 control subjects using tetra-primer ARMS-PCR followed by agarose gel electrophoresis. Serum levels of MMP-1 were determined by Elisa. Statistical analysis was applied to test the significance of the results. The genotypic and allelic distribution varied significantly between the disease group and the control subjects [OD = 1.981 (1.236–3.181), p = 0.004]. MMP-1 levels were higher in subjects homozygous for the 2G allele than in subjects with the 1G allele. The present study revealed a significant association of the MMP-1 −1607 1G/2G (rs1799750) gene promoter polymorphism with chronic pancreatitis, and it can be considered a biological marker in the etiology of chronic pancreatitis. |
| Starting Page | 644 |
| Ending Page | 654 |
| Page Count | 11 |
| File Format | |
| ISSN | 00062928 |
| Journal | Biochemical Genetics |
| Volume Number | 51 |
| Issue Number | 7-8 |
| e-ISSN | 15734927 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2013-05-05 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Matrix metalloproteinase Genotypes Pancreatic fibrosis Pancreatic stellate cells Human Genetics Biochemistry Zoology Medical Microbiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics |
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