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| Content Provider | Springer Nature Link |
|---|---|
| Author | Benrahma, Houda Charoute, Hicham Lasram, Khaled Boulouiz, Redouane Atig, Rym Kefi Ben Fakiri, Malika Rouba, Hassan Abdelhak, Sonia Barakat, Abdelhamid |
| Copyright Year | 2014 |
| Abstract | Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations. In a case–control study of 250 unrelated Moroccan diabetic patients and 250 healthy controls, we used TaqMan allelic discrimination assays to genotype the three SNPs and meta-analysis to investigate the association between the polymorphisms and diabetes in Arab populations. The results showed a significant diabetes association only with the variant rs4402960 of the IGF2BP2 gene under additive 2 (GG vs. TT; p = 0.009) and recessive (TT vs. GG+GT; p = 0.003) models. Meta-analysis indicated significant association between the IGF2BP2 rs4402960 and CDKAL1 rs7756992 polymorphisms and increased risk of diabetes in Arab populations. According to our results, the case–control study and meta-analysis revealed a significant association between the IGF2BP2 rs4402960 variant and type 2 diabetes in Moroccan and Arab populations. |
| Starting Page | 430 |
| Ending Page | 442 |
| Page Count | 13 |
| File Format | |
| ISSN | 00062928 |
| Journal | Biochemical Genetics |
| Volume Number | 52 |
| Issue Number | 9-10 |
| e-ISSN | 15734927 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2014-06-05 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | IGF2BP2 rs4402960 CDKAL1 rs7756992 KCNJ11 rs5219 Genetic susceptibility Morocco Human Genetics Biochemistry Zoology Medical Microbiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics |
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