NDLI: Characterization of Four Novel Variants of Goat βA-Globin Gene

Content Provider	Springer Nature Link
Author	Pirastru, Monica Manca, Laura Masala, Bru
Copyright Year	2003
Abstract	Four novel alleles of the adult β-globin gene of Capra hircus were observed in an extended study on hemoglobin polymorphism in goat breeds living in the island of Sardinia. Nucleotide sequencing showed that one of these alleles is due to a 2 bp substitution at codon 125 ( $$\underline {CT} \to \underline {GA} G,$$ G, "Leu→Glu). Two substitutions, the silent CT $$\underline T \to CT\underline C $$ for Leu at codon 78 and the conservative A $$\underline A G \to A\underline G $$ G (Lys →Arg) at codon 104, are shared by the other three alleles, two of them having additional mutations, which suggests a common origin. The allele we provisionally called the β Y shares four out of five amino acid substitutions, together with the same polymorphisms in the IVSII, we observed previously in the rather common β E gene. This evidence allowed the origin of the β E gene to be better characterized. The data increase to seven the number of alleles at the goat β A -globin locus characterized thus far at the molecular level. A simplified nomenclature for the increasing number of goat β-globin alleles is presented.
Starting Page	209
Ending Page	217
Page Count	9
File Format	PDF
ISSN	00062928
Journal	Biochemical Genetics
Volume Number	41
Issue Number	7-8
e-ISSN	15734927
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Medical Microbiology Biochemistry Zoology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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