NDLI: Expression of mRNA Isoforms of Latent Transforming Growth Factor-β Binding Protein-1 in Coronary Atherosclerosis and Human Tissues

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Expression of mRNA Isoforms of Latent Transforming Growth Factor-β Binding Protein-1 in Coronary Atherosclerosis and Human Tissues

Content Provider	Springer Nature Link
Author	Öklü, Rahmi Hesketh, Robin Wicky, Stephan Metcalfe, James C.
Copyright Year	2010
Abstract	Latent transforming growth factor-β binding protein-1 (LTBP1) has been implicated in the control of secretion, localization, and activation of TGFβ (transforming growth factor-β). We developed a quantitative reverse-transcriptase polymerase chain reaction (Q-RT-PCR) assay using an RNA internal standard to examine the expression of three alternatively spliced isoforms of LTBP1 (LTBP1Δ41, LTBP1Δ53, and LTBP1Δ55) in a variety of human tissues. The assays were also used to determine the expression of LTBP1L and LTBP1S isoforms and total LTBP1. The Q-RT-PCR assays were highly reproducible and showed that in most tissues LTBP1Δ55 and LTBP1L were minor components of LTBP1. The proportion of LTBP1Δ41 ranged from 2% of total LTBP1 mRNA in early coronary atherosclerotic lesions to 54% in advanced lesions.
Starting Page	213
Ending Page	225
Page Count	13
File Format	PDF
ISSN	00062928
Journal	Biochemical Genetics
Volume Number	49
Issue Number	3-4
e-ISSN	15734927
Language	English
Publisher	Springer US
Publisher Date	2010-12-15
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Latent transforming growth factor-β binding protein Q-RT-PCR Alternative splicing Genetic variation Medical Microbiology Human Genetics Biochemistry Zoology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

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